NovaMin formulations build a hydroxyapatite-like layer over and within dentine tubules
NovaMin is specially formulated in Sensodyne Repair & Protect to repair exposed dentine:*1–7
- Once in contact with saliva, NovaMin initiates a cascade of ionic exchanges
- This results in a rise in pH level in the localised environment, which allows NovaMin to bind to collagen fibres in exposed dentine
- Once bound to dentine, NovaMin particles act as calcium and phosphate reservoirs, forming a robust and reparative hydroxyapatite-like layer over exposed dentine tubules to help protect against dentine hypersensitivity pain
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection
NovaMin forms a robust hydroxyapatite-like layer over exposed dentine and within exposed dentine tubules*1,2
An in vitro cross-section, SEM image of hydroxyapatite-like layer formed by supersaturated NovaMin solution in artificial saliva after five days (no brushing).1
SEM image adapted from Earl et al. 20111SEM, scanning electron microscope *It forms a protective layer over the sensitive area of the teeth. Brush twice a day for lasting sensitivity protection
NovaMin helps form a protective layer over exposed dentine1,2
The hydroxyapatite-like layer bonds to the collagen in exposed dentine1
TEM image of dentine at 2000nm
The occluded dentine tubule runs from top to bottom of the image.1
TEM image of dentine at 500nm
High magnification showing NovaMin as the occluding material adjacent to inner wall of dentine tubule.1
TEM image of dentine at 200nm
Very high magnification of the previous image showing crystalline calcium phosphate deposited adjacent to and among collagen fibres of dentine.1
TEM, transmission electron microscope TEM images are of dentine after 5 days of in vitro NovaMin treatment and are adapted from Earl et al. 20111
NovaMin is activated in the mouth to provide protection from dentine hypersensitivity1,3,6–11
Scanning electron microscope images of the dentine surface before brushing with NovaMin-formulated toothpaste and the resistant layer formed after1
NovaMin is a Bioglass that uses the natural building blocks of teeth3 to remineralise exposed dentine, forming a crystalline hydroxyapatite layer.1,3,6–11
- Calcium and phosphorous are the two main components of hydroxyapatite, the mineral which teeth are made of – this is key to the mode of action of NovaMin
NovaMin helps create a reparative layer that is structurally similar to dentine†1,12
The Ca:P ratio of the hydroxyapatite-like layer is ~1.67, similar to that of dentine and hydroxyapatite1
When overlaid, energy-dispersive X-ray (EDX) microscopy plots of the new reparative layer† (hydroxyapatite-like layer) and the dentine surface confirm their similar inorganic compositions.
†Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection
A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated a reduction in the proportion of teeth with dentine hypersensitivity13,14
53% reduction in the proportion of teeth qualifying as sensitive in response to an evaporative air test (Schiff Sensitivity Scale) after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.*13,14
Chart adapted from GSK Data on File RH0189713*Qualifying sensitive teeth met the following inclusion criteria: signs of EAR, GI ≤1, clinical mobility=0, no dentition exclusion and sensitivity to a qualifying air blast. ITT population (n=75)
A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated improvement in dentine hypersensitivity in response to tactile pressure†13,14
2.2x improvement in dentine hypersensitivity in response to tactile pressure after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.†13,14
Chart adapted from GSK Data on File RH0189713†Maximum tactile pressure was 80g. An increase in tactile threshold indicates an improvement in dentine hypersensitivity. ITT population (n=75)
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