Pronamel Clinical Enamel Strength

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Our Best Enamel Care Science Yet*
Pronamel is clinically proven to help restore and protect enamel
Pronamel helps more fluoride penetrate deep into weakened enamel surfaces
Learn more about the formulation
Microdamage Repair was 4 Times Greater than a Leading Competitor
Pronamel Clinical Enamel Strength Deep Clean Toothpaste

NEW Pronamel Clinical Enamel Strength packaging

Our Best Enamel Care Science Yet*

Pronamel Clinical Enamel Strength delivers 50% more fluoride into the enamel surface^† for repair, strengthening and protection of acid softened enamel.^{^1}

Repairs 66% microdamage**
Clinically proven to help restore and protect enamel²
3x stronger enamel protection vs your mouth’s natural defenses²
Helps build enamel resistance for cavity and erosion protection from day one
Better cleaning action but just as gentle as Pronamel Intensive Enamel Repair³

Designed to help keep enamel forever^ǂ

*in our portfolio^with twice daily brushing†vs standard fluoride toothpaste**acid-weakened enamel. On average as shown in 7-day lab test^ǂwith continued twice daily brushing, contains fluoride

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Pronamel CES is clinically proven to help restore and protect enamel

Pronamel is clinically proven to help restore and protect enamel²

Pronamel is backed by 17 years of research and clinical studies. The optimized technology is highly effective at delivering fluoride to enamel after dietary acid attack and has been formulated without ingredients which can interfere with fluoride’s action such as polyphosphates and SLS. The formulation of Pronamel Clinical Enamel Strength was developed to optimize the effect of fluoride to boost calcium and phosphate uptake into enamel.*

*vs standard fluoride toothpaste

Pronamel delivers more fluoride deeper into the enamel surface than certain other toothpastes

Pronamel helps more fluoride penetrate deep into weakened enamel surfaces^{^4}

This study aimed to determine and visualize the enamel fluoride uptake (EFU) of toothpaste by time-of-flight secondary ion-mass spectrometry (TOF-SIMS). The focus was on determining the depth of fluoride penetration into enamel demineralized by a 15-minute acid challenge, following twice daily treatment for 7 days with a toothpaste slurry. We see from the image the fluoride uptake for a fluoride-free control as well as 3 test toothpastes.

The results show that Pronamel Clinical Enamel Strength delivers significantly more fluoride into the enamel surface than certain other toothpastes.^*4

^{^}vs standard fluoride toothpaste^*vs Colgate Renewal Enamel and Crest Pro Health Densify Active Repair, in a laboratory study, after single application and after twice daily application for 7 days

Learn more about the formulation

Patients’ enamel is susceptible to wear and erosion due to exposure to dietary acid. The process of demineralization leads to the partial loss of calcium and phosphate ions. This can result in enamel softening, changes in shape and texture and eventually sensitivity. Learn more about how Pronamel Clinical Enamel Strength replenishes the absorption of natural minerals into the enamel surface.

Learn More about the Science and Benefits of Pronamel Clinical Enamel Strength

Microdamage repair was 4 times greater than a leading competitor^{^}

Surface microhardness recovery is the measure of the acid-softened enamel surface regaining hardness after treatment and remineralization periods over a set amount of time.

The graph shows the results for treatment with Pronamel Clinical Enamel Strength after 3 days treatment.

^{^}Increases enamel hardness as seen in an vitro study (after both 3 & 7 days)
3x stronger enamel protection^*2

This graph shows results for acid resistance ratio (ARR) for Pronamel compared to a competitor and fluoride free toothpaste. ARR is a measure of enamel resistance to a post remineralization erosive challenge generated using an in situ design.

The 3x stronger enamel protection* is an expression of how fluoride uptake to enamel provides protection from acid challenges and is based on the calculation at a 2 hour timepoint compared to the mouth’s natural defenses.^*2

*vs the mouth’s natural defenses
Significantly increased the erosive resistance to further acid challenges

This study aimed to assess and visualize the ability of Pronamel Clinical Enamel Strength to protect enamel from erosive lesions.

On the images the dark areas at the enamel surface highlight the lesion depth from acid challenge. The mineral density and lesion depth data showed that the enamel samples treated with Pronamel had a significantly higher resistance to erosive lesion formation.⁵
Significantly less abrasive than other leading competitive toothpastes^3*

The formulation of Pronamel Clinical Enamel Strength has a cleaning system which uses 0.6% w/w spherical silica combined with a dual surfactant system.³ This silica system has been tested and shown to provide effective cleaning using the in vitro pellicle cleaning ratio study (PCR).

This study aimed to assess and visualize the ability of toothpaste formulations to protect human enamel against erosive lesions compared to a fluoride-free control. Human dentin samples were brushed under standardized conditions using a brushing simulator and confocal laser scanning microscopy was used to visualize surface changes and determine abrasion depths.³

*as tested in vitro in an abrasively model on dentin vs. Crest Pro-Health Density Active Repair Pro and Colgate Renewal Enamel
Can be used as part of aligner therapy⁵

New Pronamel Clinical Enamel Strength can be used before, during, and after aligner use. Clear aligners are sleeve-shaped removable full-coverage orthodontic appliances that may often require resin attachments (buttons) to be bonded to the tooth surfaces.

Due to the removable nature of clear aligners, most dentists believe that they are more conducive to oral hygiene maintenance than fixed appliances, thus contributing to better periodontal health. However, due to the long wearing time and the fact that the aligners wrap around a large area of the tooth surface, this special interaction with the teeth may limit their natural cleaning by saliva, which may be an important factor triggering enamel demineralization.

Aligner therapy patients are prone to caries, too. In fact, 28% of aligner patients developed at least one new early-stage cavity. Pronamel not only protects enamel, but also helps stop early stage cavities when used as directed.^

Use Pronamel Clinical Enamel Strength before, during, and after aligner therapy to help protect enamel.*

^with twice daily brushing*Clear Aligners and Pronamel: Making the Connection

Recommend Pronamel Clinical Enamel Strength for greater enamel protection and cavity defense

Pronamel CES Deep Clean Toothpaste Packshot

Pronamel Clinical Enamel Strength Deep Clean Toothpaste

With a dual surfactant system and spherical silicas, Pronamel Clinical Enamel Strength Deep Clean delivers 55% more effective cleaning action* but is just as gentle.

*vs Pronamel Intensive Enamel Repair