Pronamel Science

The Optimized Formulation Of Pronamel^1–9

Pronamel is designed to protect against the effects of enamel erosion due to dietary acids.

Specially designed to release more fluoride to acid-weakened enamel^2,4

Pronamel contains 1150ppm fluoride in an optimized formulation designed to maximize fluoride delivery.² By omitting components that inhibit fluoride uptake, which are present in many fluoride toothpastes, Pronamel's dual-protection formulation enhances remineralization and inhibits demineralization, strengthening and protecting enamel.^1-5

Pronamel's optimized formulation:

Delivers up to 10x higher fluoride uptake vs a non-optimized fluoride toothpaste*
No phosphates^4,6
No polyvalent metal ions
High fluoride availability⁷
No SLS**⁸
Neutral pH⁹
Enhances remineralization and inhibits demineralization^1-5

*Based on an in vitro study in which fluoride uptake was measured at 10um depth (vs. Colgate Enamel Health, sourced and tested in 2014)** Sodium Lauryl Sulfate

How enamel is affected by enamel erosion

Enamel undergoes natural dynamic cycles of remineralization and demineralization,^10-12 normally favoring remineralization due to mineral-rich saliva, which helps neutralize acidity and reharden enamel.

However, exposure to gastric or dietary acids can demineralize and weaken enamel, causing it to lose some of its mineral content. Because the tooth’s recovery process is slow, if the acid attack happens frequently, the enamel will not have a chance to repair itself.

Not all fluoride toothpastes are the same

Pronamel maintains higher levels of fluoride in saliva one hour after brushing

In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher levels of fluoride in subjects’ saliva 1 hour after brushing.¹

Adapted from GSK data on file RH02217, 2014¹
Pronamel creates an environment in the mouth that supports fast remineralization

In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher calcium bioavailability in subjects’ saliva.¹

Adapted from GSK data on file RH02217, 2014¹.*Tested on Pronamel & Colgate Sensitive Enamel Protect (both containing 1150ppm fluoride as NaF).
Pronamel’s formulation has been engineered to optimize fluoride uptake

Up to 10x higher fluoride uptake* in vitro vs. a non-optimized, 1150ppm fluoride NaF toothpaste²

In laboratory studies, Pronamel delivered more fluoride, deeper into the enamel for fast remineralization vs. a non-optimized fluoride toothpaste.*²

In vitro cross-sectional DSIMS images of enamel surfaces
Pronamel improves mineral uptake, leaving enamel more resilient to subsequent acid challenges

In an in situ study, Pronamel increased the surface microhardness of acid-weakened enamel, leaving it stronger and more resilient to dietary acid challenges,⁷ with 54% greater surface microhardness recovery vs. a non-optimized fluoride toothpaste.⁷
Pronamel helps keep teeth stronger and better-protected
Pronamel’s formulation creates an environment in the mouth that supports fast remineralization and protection from demineralization with added inactive ingredients:

Lactate, which helps enhance fluoride uptake to acid-weakened enamel surfaces.

Added co-polymer, which helps enhance acid resistance.

SEM Images of enamel cross-sections show variations in mineral density. Images taken from GSK Data on File 133333.
A gentle formulation helps ensure minimal wear of acid-weakened enamel

Pronamel has a low abrasion formula, helping to maintain the structural integrity of the enamel surface.*¹³