Diclofenac

Diclofenac inhibits cyclooxygenase enzymes, reducing inflammation at the source of pain1,2

Learn how diclofenac reduces inflammation by inhibiting prostaglandin biosynthesis through action on the cyclo-oxygenase (COX) enzymes.

It is a non-selective inhibitor of COX-1 and COX-2 (preferentially COX-2) and also reduces the production of leukotrienes by inhibiting the lipoxygenase enzyme.1,2

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Pain starts at the cellular level

Pain starts at the cellular level

Inflammatory stimuli catalyse the formation of prostaglandins, leukotrienes, and thromboxanes, which induce pain and inflammation.1,2

Voltaren is clinically proven to reduce pain and inflammation at the site of application1,2

Diclofenac inhibits COX receptors

Diclofenac inhibits COX receptors1,2

The mechanism of action of diclofenac is similar to other NSAIDs. Diclofenac is a non-selective inhibitor of cyclooxygenase 1 and 2 (preferentially COX-2), resulting in the inhibition of prostaglandin synthesis.1,2

Specially designed for absorption

Specially designed for absorption1,2

Specially formulated for absorption of diclofenac through the skin, creating a reservoir under the skin (subdermis).1,2

It preferentially distributes and persists in deep, inflamed tissues to relieve pain.1,2

Diclofenac-containing products for effective relief of acute pain1,2

Voltaren (Diclofenac Diethylamine 1.16% w/w) products

Voltaren Diclofenac Diethylamine 1.16% w/w

Relieves muscle, back & joint pain, and reduces inflammation.1

Indicated for the relief of pain associated with acute, localized muscle or joint injuries such as sprains, strains or sports injuries.1

Voltaren Emulgel Extra Strength (Diclofenac Diethylamine 2.32% w/w)

Voltaren Emulgel Extra Strength (Diclofenac Diethylamine 2.32% w/w)

Contains a permeation enhancer to increase penetration of diclofenac through the skin.2,3

Relieves muscle, back & joint pain, and reduces inflammation.2

Indicated for the relief of pain associated with acute, localized muscle or joint injuries such as sprains, strains or sports injuries.2

Voltaren – for effective relief of acute muscle, back & joint pain1,2

Conditions

Condition Information

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Voltaren products

Voltaren Products

Help your patients manage their acute pain with our pain-relieving products.

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NNT data for Diclofenac Diethylamine vs. the ideal treatment

Diclofenac Diethylamine’s NNT value

See Diclofenac Diethylamine’s NNT value in a Cochrane Review of topical NSAIDs

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