Causes of Osteoarthritis (OA) Pain

knee pain

What causes joint and OA pain?

OA is caused by a localized loss of cartilage, bone shape changes due to joint function, and associated inflammation.1 Many risk factors play into developing and being susceptible to OA, but the chances of diagnosis increase with age.2Manifestation of the disease is highly variable, but is most often associated with significant symptoms.3

Healthy knee and OA knee comparison

How does OA develop?

  • OA is a multistep process that starts with gradually losing or damaging cartilage
  • Once the cartilage is damaged, changes occur in the underlying bone, which can cause the bone to thicken or grow spurs1,5 
  • The joint components become so damaged that the joint doesn’t function properly6
  • Bone and cartilage fragments float in the synovial fluid, causing irritation and pain7
  • The synovial fluid no longer lubricates the joint correctly and loses its ability to absorb shock8
  • The synovial fluid releases inflammatory cytokines, which damage the cartilage further. The joint cavity fills with further synovial fluid, causing distension and pain9

OA causes joint damage over time, affecting body parts like the hands, spine, knees, and hips.10 OA can lead to deformed or enlarged joints, but pain is often cited as the limiting symptom.2,3 Aside from pain, bony growths, known as spurs, limited range of motion, swelling, and malalignment are other symptoms associated with OA.5,6,11

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Treat OA

How to treat OA Pain?

The latest OA treatment guidelines from the American College of Rheumatology.

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United States with OA patients

Who gets OA?

A look at which patients suffer most often.

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How is Voltaren® Arthritis Pain gel OTC different?

Learn the differences between Voltaren® Arthritis pain and the prescription version

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Drug facts

Voltaren® Arthritis Pain gel OTC Drug Facts

The drug facts contain all you need to know about dosing and administration.

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MOA molecule

How does Voltaren® Arthritis Pain gel OTC penetrate the skin?

The science behind Voltaren® Arthritis Pain and its MOA.

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How does Voltaren® Arthritis Pain gel OTC work?

See how effective Voltaren® Arthritis Pain is on OA of the knee.

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