Centrum Science
Daily use of Centrum Silver for 3 years may slow cognitive aging by 60%†*
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
An Expert’s Opinion – Maggie Moon
Supporting Cognitive Health Starts with the Right Nutrients
Optimal cognitive function and memory not only contributes to independence, self-identity and relationships, but also elevates a general sense of well-being. This makes cognitive health key to thriving as we age.
Watch as Maggie Moon, a registered dietitian and specialist in brain health, discusses how food alone may not be enough to help older adults meet all their nutritional needs. That’s why the micronutrients found in supplements like Centrum Silver play an important role in bridging that gap.
For more information from Maggie Moon, a paid sponsor for Centrum, watch the full series.
Can nutrition play a role in supporting memory with age?
Micronutrients play a vital role in multiple biochemical processes that can affect brain function and how we age, however it’s estimated that more than 2 billion people worldwide are insufficient in key vitamins and minerals.9 This concern is magnified in older populations, as diminished gastric acid production, medication use and chronic conditions can all affect micronutrient absorption.2
That’s why the micronutrients found in supplements like Centrum Silver can help bridge that gap by supporting optimal nutrient intake and promoting cognitive well-being. Understanding how we can support cognitive health is key to promoting the overall wellness of our aging population.
The #1 Doctor recommended multivitamin brand
Centrum Silver is Clinically Proven to Support Memory in Older Adults
Three large-scale, long-term clinical trials with over 5,000 participants showed daily use of Centrum Silver tablets support cognitive aging in older adults compared to placebo. ⧺1,3
- The COSMOS-Mind study showed that daily intake of Centrum Silver over 3 years, as compared to placebo, significantly improved performance on global cognitive function, memory and executive function tests in older adults. It was estimated that daily use may slow cognitive aging by up to 60%.†
- The COSMOS-Web study demonstrated that daily use of Centrum Silver, as compared to placebo, significantly improved performance on memory tests in older adults with benefits seen in just one year. The difference in performance between Centrum Silver and placebo was estimated to reflect a difference of 3.1 years of age-related change.††
- The COSMOS-Clinic study – demonstrated that daily use of Centrum Silver over 2 years led to a statistically significant favorable change in performance on memory tests as compared to placebo.
- The COSMOS-Clinic Meta-analysis - Analyzed data of over 5,000 non-overlapping participants and showed that daily use of Centrum silver led to a significantly more favorable change in memory and global cognitive function among older adults than placebo.
The combined analysis of 3 studies establish that daily use of Centrum Silver can benefit memory.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
†Predicted model used to estimate age-related cognitive decline within the study with observed treatment-related protection against cognitive ageing of 1.8 years in 3 years.
†† Estimated via a cross-sectional regression analysis between age and ModRey Immediate Recall test wherein the expected memory decline for each year of ageing was derived from the 3-year COSMOS-Web randomized controlled trial, which randomly assigned participants to either a daily Centrum Silver supplement or placebo for the duration of the study.
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COSMOS-Mind Study Overview
COSMOS-Mind Study Overview
COSMOS-Mind was the first large-scale, long-term, randomized controlled trial to assess the effects of daily Centrum Silver multivitamin use on adults 65+ measuring cognitive function according to 3 criteria:
- Global cognitive function—an umbrella term that refers to various aspects of cognitive performance like orientation, recall, attention, calculation, and language.3,8
- Episodic memory—the ability to encode, store, and recollect learned events.4,8
- Executive function—the ability to carry out goal-directed behavior through strategy, planning, and awareness of information.4,8
Objective:
- To examine the effects of daily Centrum Silver multivitamin use on cognitive function over 3 years
Method:
- Cognition was assessed by baseline and annual telephone-based assessments for 3 years
Primary endpoint:
- Change in global cognition composite score over 3 years with daily Centrum Silver multivitamin use
Secondary endpoint:
- Change in episodic memory and executive function with 3 years of daily Centrum Silver multivitamin use
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COSMOS Mind Study Results
COSMOS-Mind provides evidence that daily use of Centrum Silver can support memory and cognition in older adults.
Key results:
- Daily use of Centrum Silver significantly improved performance on cognitive function tests in older adults as compared to placebo.
- Centrum Silver significantly improved performance on memory and executive function tests as compared to placebo.
- Among individuals with a history of cardiovascular disease (CVD) those that took Centrum Silver showed a significant increase in cognitive function performance after 2 years.
Conclusion:
Daily supplementation with Centrum Silver is a safe,** readily accessible, and affordable intervention that can support cognitive function and memory in older people.
†Based on predictive model used to estimate age-related cognitive decline within the study with observed treatment-related protection against cognitive aging of 1.8 years in 3 years.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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COSMOS-Web Study Overview
COSMOS-Web Study Overview
COSMOS-Web was a large-scale, long-term randomized control trial that examined the effect of daily Centrum Silver supplementation on memory in older adults. This is the second of three significant clinical trials that have studied the effect of Centrum Silver multivitamins on cognitive health.
Methods:
- Memory was evaluated at baseline and annually for 3 years using an internet-based range of neuropsychological tests.
Primary endpoint:
- Change in memory scores after 1 year of intervention.
Secondary endpoint:
- Change in memory scores after 2 and 3 years of intervention.
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COSMOS Web Study Results
COSMOS Web Study Results
The COSMOS-Web study confirmed the memory findings from COSMOS-Mind5 and the benefit of Centrum Silver supplementation on memory in older adults.
Key Results:
- Daily use of Centrum Silver significantly improves performance on memory tests in older adults with benefits seen in just one year.
- The effect of Centrum Silver supplementation was sustained over 3 years.
- The effect of Centrum Silver supplementation on the improvement in memory at 1 year was greater than placebo in participants with a history of CVD vs no history of CVD.
Conclusion:
Daily use of Centrum Silver multivitamin significantly improved performance on memory tests in older adults at one year, an effect that was sustained over the duration of the trial.
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
†† Estimated via a cross-sectional regression analysis between age and ModRey Immediate Recall test wherein the expected memory decline for each year of ageing was derived from the 3-year COSMOS-Web randomised controlled trial, which randomly assigned participants to either a daily Centrum Silver supplement or placebo for the duration of the study.
Beyond Multivitamins – How can you support your patients’ cognitive health?
Here are 4 simple tips that you can share with your patients:
Pronamel's optimized formulation:
- Stay socially active – Close relationships with family and friends, as well as participating in meaningful social activities, may help maintain thinking skills and slow cognitive decline.10
- Keep learning – Developing a high cognitive reserve may make us more resilient to the effects of aging.10,11 Education, an engaging occupation, mentally stimulating activities, learning, and social interactions may help to build cogntivie reserve.10-12
- Exercise – Physical exercise enhances cognitive function, improves memory abilities, and prevents cognitive decline linked to aging.13
- Maintain a healthy diet – Numerous studies show a high-quality diet (e.g. Mediterranean diet) is associated with a reduced risk of cognitive impairment14,15
The #1 Doctor recommended multivitamin brand
Recommend Centrum Silver
Our Centrum Silver products come in a variety of forms to fit your patients needs including:
- Tablets - have a smooth, clear outer coating that makes them easy-to-swallow
- Gummies - Contains no artificial dyes or artificial sweeteners and are gluten free in a variety of natural fruit flavors
- Mini’s – (2) Daily easy-to-swallow mini tablets that are 50% smaller than Centrum Silver tablets with the same nutritional benefits Provide your patients with the essential daily nutrients they need for whole-body health.
Provide your patients with the essential daily nutrients they need for whole-body health.
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Centrum: An Expert’s Opinion
Maggie Moon, a registered dietitian and specialist in brain health, explains the latest nutrition science and the potential benefits of multivitamins for older adults.
