Panadol Baby & Infant

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Panadol Baby & Infant pack shot

Tough** on fever and pain,1 gentle1,3¶on the child†

Panadol Baby Infant contains paracetamol, which is recommended as first-line treatment for fever and mild-to-moderate pain in children.2-4 It starts to relieve fever within 15 -30 minutes of dosing.1,5-7

Chart adapted from the World Health Organization guidelines on fever management in children

The World Health Organization guidelines on fever management state that when a child presents with fever, danger signs should be looked for. These include an inability to drink, persistent vomiting, convulsions, lethargy or unconsciousness, stridor in a calm child or severe malnutrition. If these signs are present, the patient must be referred immediately for specialist management.8

The symptomatic fever, associated with distress due to non-specific respiratory infections, diarrhoea and other infections, is managed with paracetamol.2

Chart showing reduction of temperature after paracetamol. Adapted from Wong et al. 2001.

This was a randomised, double-blind multicentre trial involving febrile children aged 6 months to 6 years who were given a dose of paracetamol (acetaminophen) 12 mg/kg (n=210). A downward slope in temperature was seen at the 15-minute time point. Maximal rate of temperature reduction was reached at 60 minutes in the paracetamol group.6

As effective as ibuprofen at doses of 10 mg/kg9

Chart showing the reduction of temperature in children given paracetamol 10 mg/kg or ibuprofen 10 mg/kg. Adapted from Vauzelle et al. 1997

This was a randomised, double blind, multicentre trial with 116 children aged 4.1 years (± 2.6 years) with a fever related to an infectious disease and a mean baseline temperature of 39°C (± 0.5°C), who were treated with either single doses of ibuprofen 10.3 mg/kg (± 1.9 mg/kg) or paracetamol 9.8 mg/kg (± 1.9 mg/kg). The children’s rectal temperature was regularly monitored for 6 hours. Tmax is the time that elapsed between first dose of drug administration and lowest temperature observed between the 0-6 hours.9

When given to children with fever, both paracetamol 10 mg/kg and ibuprofen 10 mg/kg were similar in reduction of temperature in the time between dosing and achieving lowest temperature during 0-6 hours.9

Chart showing the reduction of temperature in children given paracetamol 15 mg/kg or ibuprofen 10 mg/kg. Adapted from Autret-Leca et al. 2007

A randomised, single-dose, double-blind study in children from 3 months to 12 years old (N = 301) with non-serious fever received either paracetamol 15 mg/kg or ibuprofen 10 mg/kg. Mean temperature in both groups were 38.9°C at baseline. Primary outcome was tympanic temperature reduction over the following 8 hours post first dose administration.

Both paracetamol 15 mg/kg and ibuprofen 10 mg/kg had similar (not significant) reductions in temperature. The mean area under the curve (AUC) was -7.66°C and -7.77°C, respectively.10

Effective as pain-relief in children11

Chart showing significant pain relief from paracetamol vs. placebo as assessed by children and their parents. Adapted from Schactel et al. 1993.

This was a randomised, single-dose, double-blind, placebo-controlled study in children aged 2-12 years with acute sore throat treated with paracetamol 15 mg/kg, ibuprofen 10 mg/kg or placebo. Paracetamol showed significant pain relief vs. placebo from 1-hour post dose, which was sustained until 4 hours after dosing based on the children’s assessment of their pain.The parents’ assessment of changes in pain intensity seen in their children reflected the same.11

An unsurpassed tolerability profile among children’s over-the counter analgesics/antipyretics3,12

Happy child with his mother

When compared to non-steroidal anti-inflammatory drugs (NSAIDs) e.g. ibuprofen, paracetamol is preferred because it is gentle on tiny tummies,1,3 has a lower risk of bleeding complications in certain vector-borne diseases like dengue2 may be suitable for children with dehydration12 and does not interact with as many other medicines like ibuprofen does.2

In a literature review of 23 clinical studies of paracetamol involving children, the safety data showed that paracetamol had comparable safety to ibuprofen and ketoprofen in short-term treatment of fever.3

What can Panadol Baby Infant do for Ollie?

Baby smiling

Ollie’s got a fever

Ollie’s 1 years old and has been having a fever for the past two days. His mum is worried because he’s been fussy and not eating well. She wants something to help him get rid of the fever and at the same time, something that is suitable for him.

Panadol Baby & Infant from 2 months to 12 years old suspension with strawberry flavour would help Ollie feel better by reducing his fever quickly, effectively and safely.

Panadol Baby & Infant comes Suspension formulation

Panadol Baby & Infant pack shot

Panadol Baby & Infant from 2 Months to 12 years suspension with strawberry flavour

Panadol Baby & Infant product details

  • Panadol Baby & Infant from 2 Months to 12 years suspension with Strawberry Flavour

    Ingredients: Paracetamol 120 mg/5ml

    Other Ingredients: Hexacol Carmoisine Supra (E122), Malic Acid, Keltrol F (Xanthan Gum), Maltitol Syrup, Strawberry Flavour L10055, Sorbitol Liquid (Crystallising), Sodium methyl paraben (E219), Sodium ethyl paraben (E215), Sodium propyl paraben (E217), Sorbitol Powder, Citric Acid, Purified Water.

    mentioned as

    important information about some of the ingredients in Panadol Baby and Infant:

    • If the child has known rare hereditary problems such as intolerance to some sugars, contact your doctor before use as this product contains maltitol syrup and sorbitol.
    • The preservatives Sodium methyl paraben (E219), Sodium ethyl paraben (E215) and Sodium propylparaben (E217) may cause allergic reactions (possibly delayed).
    • The colouring agent Hexacol Carmoisine Supra (E122) may cause allergic reactions.

    Contains parahydroxybenzoates which may cause allergic reactions.

    Do not give Panadol Baby and Infant to the child:

    • If the child is allergic to paracetamol or any of the ingredients listed in section 6.
    • If the child is taking any other medicines containing paracetamol.
    • If the child has a known intolerance to the sugar called fructose.
    • Take special care with Panadol Baby and Infant

    Please see your doctor before you give Panadol Baby and Infant to the child if:

    • The child suffers from liver or kidney problems.
    • The child is underweight or malnourished.
    • In patients with glutathione depleted states such as sepsis, the use of paracetamol may increase the risk of metabolic acidosis.
    • The baby was born prematurely and is under 3 months
    • Taking other medicines

    Please see your doctor before you give Panadol Baby and Infant to the child if:

    • The child is taking metoclopramide or domperidone (used to treat nausea and vomiting) or cholestyramine (used to treat high cholesterol).
    • The child is taking warfarin or other drugs used to prevent blood clotting.
    • The child is taking any prescribed drugs or is under the care of a doctor.
    • Please tell your doctor or pharmacist if your baby is taking or has recently taken any other medicines, including medicines obtained without a prescription.
    • Never give more medicine than recommended dose.
    • Always use the spoon supplied with the pack.
    • Always use the lowest effective dose to relieve the child’s symptoms.
    • Do not give to babies less than 2 months of age.
    • Do not give more than 2 doses.
    • Leave at least 4 hours between doses

    Pregnancy and breastfeeding

    • Talk to your doctor before taking Panadol Baby and Infant if you are pregnant.
    • Paracetamol is excreted in breast milk. However, the level of paracetamol present is not considered to be harmful.
    • Always seek medical advice before taking any medicine during pregnancy or lactation

    If you give too much to the child

    Immediate medical advice should be sought in the event of overdosage because of the risk of irreversible liver damage even if symptoms of overdose are not present

    Body system

    Undesirable effect

    Blood and lymphatic system disorders

    Thrombocytopenia

    Immune system disorders

    Anaphylaxis

    Cutaneous hypersensitivity reactions including among others, skin rashes, angioedema, Steven Johnson syndrome and toxic epidermal necrolysis

    Respiratory, thoracic and mediastinal disorders

    Bronchospasm in patients sensitive to aspirin and other NSAIDs

    Hepatobiliary disorders

    Hepatic dysfunction

Learn more

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Managing children’s fever and pain

Tailor made for pharmacists, this tool is an excellent guide to help you manage children with fever or pain.

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When to refer children with fever

Learn more about “red-flag” symptoms when children present with fever.

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Clinical Trial

Clinical Study

An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.

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