Please consult the summary of product characteristics for full product information.
Panadol 500mg Film Coated Tablets, Panadol Actifast Tablets 500mg, Panadol Actifast 500mg Soluble Tablets (paracetamol), Panadol Extra Film-coated Tablets Paracetamol 500mg Caffeine 65mg, Panadol Extra 500mg/65mg Soluble Effervescent Tablets (paracetamol, caffeine), Panadol Night Film-coated Tablets (paracetamol, diphenhydramine hydrochloride). Indications 500mg Film Coated, Actifast Tablets, Actifast Soluble Tablets & Extra Soluble Effervescent Tablets: Short-term management of headaches, musculoskeletal disorders, menstrual pains, toothache, and relief of fever, aches and pains of colds and flu. 500mg Film Coated Tablets, Actifast Soluble Tablets: mild to moderate osteoarthritis pain diagnosed by a doctor. Night: Short-term treatment of bedtime symptoms of cold and flu pain, rheumatic and muscle pain, backache, toothache, headache, menstrual pain. Dosage Minimum dosing interval between paracetamol containing products is 4 hours. The lowest dose necessary to achieve efficacy should be used. Max 4 doses in 24 hours. All except 500mg Film Coated Tablets and Actifast Tablets: Refer to SPC for specific guidance on use in patients with hepatic and renal impairment. 500mg Film Coated Tablets: Adults and children 16 years and over: 1-2 tablets, up to 4 times daily as required. Children aged 10-15 years of age: 1 tablet, up to 4 times daily as required. Do not give to children for more than 3 days without consulting a doctor. Not recommended for children under 10 years. Actifast Tablets: Adults and children 16 years and over: 1-2 tablets up to 4 times daily as required. Children aged 12-15 years: 1 tablet up to 4 times daily as required. Do not give to children for more than 3 days without consulting a doctor. Not recommended for children under 12 years. Actifast Soluble Tablets: Adults and children 16 years and over: 1-2 tablets dissolved in water up to 4 times daily as required. Children aged 10-15 years: 1 tablet dissolved in water up to 4 times daily as required. Do not give to children for more than 3 days without consulting a doctor. Not recommended in children under 10 years. Extra Film-Coated Tablets and Extra Soluble Effervescent Tablets: Adults and children 16 years and over: 2 tablets up to 4 times a day. Children aged 12-15 years: 1 tablet up to 4 times a day. Do not give to children under 12 years. Night: Adults and children 16 years and over: 2 tablets, 20 minutes before bed. Children aged 12-15 years: 1 tablet, 20 minutes before bed. Other products containing paracetamol may be taken during the day, but the total daily dose of paracetamol must not exceed 4000mg for adults and children 16 years and over, and 2000mg for children aged 12-15 years. Not recommended for children under 12 years except on medical advice. Do not use for more than 7 consecutive nights without medical advice. Contraindications All: Hypersensitivity to paracetamol or any of the other ingredients. Night: Closed angle glaucoma, porphyria. Precautions All: Do not use with any other paracetamol-containing products. Caution, regarding paracetamol, if used at therapeutic doses for a prolonged period or administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism). If suspected, discontinue use promptly and monitor closely, including measurement of urinary 5-oxoproline. If symptoms persist, seek medical advice. All (except Night): Prolonged use except under medical supervision may be harmful. All (except Actifast Soluble Tablets): Those with underlying liver or kidney impairment should seek advice before using. 500mg film coated tablets, Actifast Tablets, Night: Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, chronic alcoholism, sepsis or who are severely malnourished, anorexic, low body mass index. Actifast Soluble tablets, Extra Film-coated tablets, Extra Soluble Tablets: Use in caution in patients with one or more risk factors for hepatotoxicity including low body weight (<50kg), renal and hepatic impairment, chronic alcoholism, concomitant use of hepatotoxic drugs, sepsis and in acute and chronic malnutrition (low reserves of hepatic glutathione). Extra Film-coated tablets, Extra Soluble Tablets: Use with caution in patients taking drugs that induce hepatic enzymes and with conditions which may predispose to glutathione deficiency. Review paracetamol doses at clinically appropriate intervals and monitor for emergence of new risk factors for hepatoxicity which may warrant dosage adjustment. Consult a doctor if high fever, or signs of secondary infection occur, or if symptoms persist for longer than 3 days. Actifast Tablets: Contains 352 mg sodium per 2 tablet dose, use with caution in those on a low sodium diet. Actifast Soluble Tablets: Contains 854mg sodium and 100mg sorbitol powder (E420) per 2 tablet dose. Use in caution in those on a low sodium diet and patients with rare hereditary fructose intolerance should not take this medicine. Extra Film coated Tablets and Extra Soluble Effervescent Tablets: Avoid excessive caffeine intake. Extra Film coated Tablets: Contain sodium methyl parahydroxybenzoate (E219), Sodium ethyl parahydroxybenzoate (E215) and Sodium propyl parahydroxybenzoate (E217) which may cause allergic reactions (possibly delayed). Extra Soluble Effervescent Tablets: Each tablet contains 427 mg of sodium and 50mg sorbitol. Caution in those on a low sodium diet and those with rare hereditary fructose intolerance should not take this medicine. Night: Avoid use with alcohol and other antihistamine containing products. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency, the Lapp lactase deficiency or of glucose-galactose malabsorption or lactase deficiency should not take this medicine. Seek medical advice before concurrent use with sedatives drugs that may cause sedation (including tranquilizers, hypnotics and anxiolytics). Use with caution in: the elderly and avoid use in elderly patients with confusion, patients with epilepsy or seizure disorders, myasthenia gravis, narrow angle glaucoma, prostatic hypertrophy, urinary retention, asthma, bronchitis, COPD, moderate to severe renal or hepatic impairment, patients taking antimuscarinics and MAOIs or within 2 weeks of stopping them, antimuscarinics. Side Effects For a full list of side effects please refer to the relevant SPC. All: (Paracetamol)Very rare: Thrombocytopenia, bronchospasm, hepatic dysfunction, anaphylaxis, cutaneous hypersensitivity reactions including skin rash, angioedema, Stevens-Johnson syndrome, Toxic Epidermal Necrolysis, serious skin reactions. Not Known: High anion metabolic acidosis. Extra Film-coated Tablets and Extra Soluble Effervescent Tablets: (Caffeine) Not known: nervousness, dizziness, palpitation, insomnia, restlessness, anxiety, irritability, gastrointestinal disturbances. Night: (Diphenhydramine) Common: Fatigue, sedation, drowsiness, attention disturbance, dizziness, unsteadiness, dry mouth. All other side effects have a not known frequency, see the SPC for details. Legal Category 500 mg Film Coated: 12s GSL; 24s Pharmacy Only. Actifast Tablets: 10s GSL; 20s Pharmacy Only. Actifast Soluble Tablets: 12s GSL; 24s Pharmacy Only. Extra Film-coated Tablets: 12s GSL; 24s Pharmacy Only. Extra Soluble Effervescent Tablets & Night: Pharmacy Only. MA Number: 500 mg Film coated Tablets: PA 678/107/1; Actifast Tablets: PA 678/39/12; Actifast Soluble Tablets: PA 678/39/14 Extra Film-coated Tablets: PA 678/27/1 Extra Soluble Effervescent Tablets: PA 678/39/10; Night: PA 678/39/8. MA Holder: Haleon Ireland Limited, Clocherane, Youghal Road, Dungarvan, Co. Waterford, X35 Y983, Ireland. Text prepared: March 2026. Further information available on request.
Contains Paracetamol. Always read the label/leaflet.
