Allergy: Overview

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Allergy

Allergies are the body’s natural reaction in response to certain allergens such as pollen or pet dander.1-4 This immune response results in the release of multiple inflammatory mediators that are responsible for allergy symptoms, including runny nose, sneezing, nasal itching, nasal congestion, and itchy eyes.5

In addition to recommendations associated with allergen avoidance, antihistamines or intranasal corticosteroids are a main recommendation for management of symptoms of allergic rhinitis.6 This includes pollen allergies, house dust mite allergies and confirmed animal allergy.6

Regular intranasal corticosteroids are recommended if the person has moderate-to-severe symptoms, or initial drug treatment is ineffective.6 They have been shown to be superior to oral antihistamines alone and act on nasal congestion.7

Allergic rhinitis can significantly impact daily activities8

  • Product information – Pirinase Allergy

    Full information can be found in the Summary of Product Characteristics.

    Pirinase Allergy 0.05% w/w Nasal Spray (fluticasone propionate). Uses: Prevention and treatment of allergic rhinitis. Dosage and method of use: Adults and adolescents aged 12 years and over: Two sprays into each nostril once a day. Twice a day may be required in some cases. Maintenance: one spray per nostril once a day if possible. Use lowest possible maintenance dose. Max 4 sprays a day in each nostril. Children under 12 years: Not to be used. Contraindications: Hypersensitivity to ingredients Concomitant use with HIV medicines. Precautions: Stop treatment or seek medical advice if improvement is not seen within 7 days. Seek medical advice if relief is inadequate, or if more than 3 months continuous use is required. Seek medical advice before use with: other corticosteroid products, fever, nasal/sinus infection (treat appropriately), recent nasal injury/surgery, nasal ulceration. Caution due to interactions with cytochrome P450 3A4 inhibitors may increase systemic exposure to fluticasone. Caution commencing in those withdrawing from systemic steroids and commencing therapy with intranasal fluticasone propionate, particularly if impairment of adrenal function suspected. Treatment with higher than recommended doses of nasal corticosteroids may result in clinically significant adrenal suppression. If there is evidence of higher than recommended doses being used then additional systemic corticosteroid cover should be considered during periods of stress or elective surgery. Systemic effects of nasal corticosteroids may occur, particularly at high doses prescribed for prolonged periods. May cause visual disturbance. Blurred vision or other visual disturbances should be considered for referral to an ophthalmologist for evaluation. Contains benzalkonium chloride which may cause bronchospasm. Side effects: Very Common: epistaxis. Common: Dryness and irritation of the nose and throat, unpleasant taste and smell, headache. See SPC for full details. Legal category: P. PL number: PL 44673/0099. Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. Package quantity and MRSP (excl. VAT): 60 sprays £7.24; 120 sprays £11.66. Date of last revision: December 2025.

  • Product information – Piriton Syrup and Piriton Allergy Tablets

    Full information can be found in the Summary of Product Characteristics.

    Piriton Children’s Allergy Syrup and Piriton Allergy Tablets (chlorphenamine maleate) Indications: Symptomatic relief of allergic conditions including hay fever. Symptomatic relief of itch associated with chickenpox. Dosage and method of use: Adults and children 12 years and over: 10ml or 1 tablet (4mg) 4-6 hourly. Max 60ml or 6 tablets (24mg) in any 24 hours. Elderly: Lower dose should be considered. Children 6-12 years: 5 ml or 1/2 tablet (2mg) 4-6 hourly. Max 30ml or 3 tablets (12mg) in any 24 hours. Syrup only: Children 2-6 years: 2.5 ml (1 mg) 4-6 hourly. Max 15ml (6 mg) in any 24 hours. Children 1-2 years: 2.5 ml (1 mg), twice daily. Max 5ml (2 mg) in any 24 hours. Piriton Allergy Tablets not recommended for children under 6 years and Piriton Syrup not recommended for children below 1 year. Do not use either product continuously for more than two weeks without consulting a doctor. Contraindications: Hypersensitivity to antihistamines or the product ingredients. Treatment with MAOIs within last 14 days. Warnings and Precautions: Avoid concurrent use with other antihistamines and alcohol. May seriously affect ability to drive and use machinery. Caution in patients with: enlarged prostate, severe hypertension or cardiovascular disease, hepatic or renal impairment, epilepsy, raised intraocular pressure, bronchitis, bronchiectasis and asthma. Children and elderly more likely to experience neurological anticholinergic effects and paradoxical excitation. Avoid use in elderly patients with confusion. Avoid concurrent use with drugs which cause sedation. Those with fructose or galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption or sucrose-isomaltase insufficiency should not take these medicines. Syrup: Contains sucrose (should be considered in those with diabetes mellitus, ensure adequate dental hygiene is maintained), hydroxybenzoates (E218, E214, E216) which may cause allergic reactions (possibly delayed), and ethanol (6.3% v/v) (should be considered in those suffering from alcoholism and other high risk groups). Side effects: Very common: Sedation, somnolence. Common: Fatigue, disturbance in attention, abnormal coordination, dizziness, headache, blurred vision, nausea, dry mouth. See SPC for full details. Legal category: P. PL numbers: Syrup: PL 44673/0094. Tablets: PL 44673/0093. Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. Package quantity and RSP (excl. VAT): Syrup: 150 ml £5.83. Tablets: 30s £5.21, 60s £8.33. Date of last revision: December 2025.

  • Product Information – Piriteze

    Full information can be found in the Summary of Product Characteristics.

    Piriteze Hayfever & Allergy 10mg Film Coated Tablets, Piriteze Children's Hayfever & Allergy 1mg/ml Syrup (GSL)and Piriteze Children's Hayfever & Allergy 1mg/ml Syrup (P) (cetirizine hydrochloride). Indication: Symptomatic treatment of seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria. Dosage and method of use: Adults and adolescents over 12 years: 10mg once daily. Children 6-12 years: 5 mg twice daily. Elderly: As adults if renal function normal. Syrups only: Children 2 to 6 years: 2.5mg twice daily. Tablets not recommended for children under 6 years and syrups not recommended in for Children under 2 years. Adjust dose in moderate to severe renal impairment. See SPC for details. Contraindications: Hypersensitivity to ingredients, hydroxyzine, piperazine derivatives or severe renal impairment (creatinine clearance <10 ml/min). Warnings and Precautions: Concomitant alcohol. Predisposition factors of urinary retention (e.g. spinal cord lesion, prostatic hyperplasia). Epilepsy/risk of convulsions. Pruritus and/or urticaria may occur when cetirizine stopped, may require treatment to be restarted. Allergy skin tests are inhibited by antihistamines, a wash out period (3 days) is required before performing them. Tablets: Not suitable for those with galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Syrup: Not to be taken by those with fructose intolerance. Contains methyl and propyl parahydroxybenzoate which may cause allergic reactions (possibly delayed). Side effects: Uncommon: Agitation, paraesthesia, diarrhoea, pruritus, rash, asthenia, malaise. All other side effects are rare, very rare or have an unknown frequency see SPC for full details. Legal category: GSL: Syrup (6years+) and Tablets: 70ml/ 7, 14, 30 P: Syrup (2years+): 70ml. PL numbers: Tablets: PL 44673/0097. Syrup (GSL): PL 44673/0095. Syrup (P): PL 44673/0096. Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, United Kingdom Package quantity and RSP (excl. VAT): Tablets: 7s £3.73, 14s £6.66, 30s £9.16. Syrup (GSL): 70 ml £5.41. Syrup (P): 70ml £5.41 Date of last revision: December 2025.

  • Product Information - Pirinase Hayfever

    Full information can be found in the Summary of Product Characteristics.

    Pirinase Hayfever Once Daily 0.05% Nasal Spray (fluticasone propionate). Indications: Treatment of seasonal allergic rhinitis. Dosage and method of use: Adults: Two sprays into each nostril once a day, preferably in the morning. Maintenance: one spray per nostril once a day, if symptoms recur the dosage may be increased accordingly. Use lowest possible maintenance dose. Max 2 sprays a day in each nostril. Children under 18 years: Not to be used. Contraindications: Hypersensitivity to ingredients. Concomitant use with HIV medicines. Warnings & Precautions: Stop treatment or seek advice if an improvement is not seen within 7 days. Seek medical advice if relief is inadequate after 7 days or more than 1-month continuous use is required. Seek medical advice before use with: other corticosteroids, nasal/sinus infection, recent nasal injury/surgery, nasal ulceration. Caution due to interactions with potent cytochrome P450 3A4 inhibitors which may increase systemic exposure to fluticasone. Treatment with higher than recommended doses of nasal corticosteroids may result in clinically significant adrenal suppression. If there is evidence of higher than recommended doses being used then additional systemic corticosteroid cover should be considered during periods of stress or elective surgery. Systemic effects of nasal corticosteroids may occur, particularly at high doses prescribed for prolonged periods. May cause visual disturbance. Blurred vision or other visual disturbances should be considered for referral to an ophthalmologist for evaluation. Contains benzalkonium chloride which may cause bronchospasm. Side effects: See SPC for full details. Very Common: Epistaxsis. Common: Headache, unpleasant taste and smell, dryness and irritation of the nose and throat. Legal category: GSL. Product licence number: PL 44673/0100. MAH: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. RRP (excl. VAT): 60 sprays £7.92. Text prepared: December 2025.

  • Product Information - Pirilieve

    Full information can be found in the Summary of Product Characteristics.

    Pirilieve Hayfever Relief 120mg Film-Coated Tablets (fexofenadine hydrochloride). Indication: Relief of symptoms associated with seasonal allergic rhinitis. Dosage and method of use: Adults and children over 12 years: 120 mg daily before a meal. Children under 12 years: Not recommended. Contraindications: Hypersensitivity to fexofenadine hydrochloride or to any of the excipients. Warnings and Precautions: Use in patients with a history of or ongoing cardiovascular disease only on a doctor's advice, due to association with adverse reactions such as tachycardia and palpitations. Use in elderly or renally/hepatically impaired patients only on a doctor's advice. Essentially ‘sodium-free’. Side effects: Common: Headache, drowsiness, dizziness, nausea. Uncommon: Fatigue. See SPC for full details. Legal category: GSL. PL number: PL 13931/0140. Product licence holder: Chanelle Medical Unlimited Company, Dublin Road, Loughrea, Co. Galway, Ireland. Distributor: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, United Kingdom. Package quantity and RSP (excl. VAT): Tablets: 30s £9.60. Date of last revision: Nov 2024.

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Pirinase Allergy 0.05% Nasal Spray (fluticasone propionate)

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