Xylometazoline hydrochloride formulations

xylometazoline

Xylometazoline constricts dilated blood vessels in the nasal mucosa1,2

Xylometazoline is a sympathomimetic agent that binds to alpha adrenergic receptors causing vasoconstriction leading to decongestion of the nasal mucosa.1,2 This effect begins to take effect within 2 minutes of application and may remain active for up to 12 hours.1

To come from Graf P, Eccles R, Chen S. Efficacy and safety of intranasal xylometazoline and ipratropium in patients with common cold. Expert Opin Pharmacother. 2009 Apr;10(5):889-908

A clinical study with xylometazoline demonstrated superiority to placebo at relieving nasal congestion3

Nasal sprays containing xylometazoline are proven to be significantly superior to placebo at relieving nasal congestion with decongestion effects shown for up to 12 hours.1,3 Xylometazoline was also found to significantly improve individual common cold symptoms, such as easier breathing, leading to significantly greater patient satisfaction with treatment.3 The activity of xylometazoline occurs as quickly as within 2 minutes.1

Xylometazoline provides rapid and long-lasting relief of nasal congestion1

  • Xylometazoline Hydrochloridescience image

    Strong vasoconstriction of dilated blood vessels in the nasal mucosa1,2

    Vasoconstriction subsequently results in decongestion of the nasal mucosa and neighbouring tissues of the pharynx, improving nasal airflow.1,2

    Xlyo structure

    Benefits of topical decongestants

    Topical decongestants in the form of nasal sprays, provide several advantages over oral decongestants:

    • They act locally on the nasal mucosa as opposed to requiring absorption and transportation through the bloodstream
    • Relief is immediate within a matter of minutes2
    • They provide a longer duration of action2
    • They have minimal systemic absorption and subsequently fewer systemic side effects4

  • Woman smiling in hammock

    Xylometazoline hydrochloride begins to take effect within 2 minutes of application and may remain active for up to 12 hours.1 This is in contrast to oral decongestants, which may take up to half an hour to come into effect and last for only up to 6 hours.2

  • Clinician with patient

    Common side effects, with an incidence of approximately 10%, include dryness or irritation of the nasal mucosa, nausea, headache, or a local burning sensation.1 Occurring at a much lower incidence of approximately 0.0001%, are allergic reactions, including difficulty breathing or swallowing, swelling of the face, lips, tongue or throat, blurred vision, and irregular heartbeat.1

    Xylometazoline is known to interact with certain antidepressant medications, including monoamine oxidase inhibitors and tri- or tetra-cyclic antidepressants; the cardiovascular effects of these substances may result in increased blood pressure.1

    Caution and appropriate medical advice should be applied before using xylometazoline in pregnancy or breastfeeding.1 Furthermore, caution should be exercised in those suffering from hypertension, cardiovascular disease, hyperthyroidism, diabetes mellitus, phaeochromocytoma, and prostatic hypertrophy.1

  • Woman blowing nose

    Rebound congestion occurs with the overuse or repetitive use of topical nasal decongestants for greater than 10 days.5 Xylometazoline is not recommended for use in durations greater than 7 consecutive days or 10 days (in the case of 0.05% and 0.1% concentrations).

    To avoid rebound congestion, patients should be instructed not to exceed the recommended dose and duration; if symptoms are not adequately controlled after the recommended maximum duration,1,5 then patients should be advised to seek medical advice from an appropriately qualified clinician.1 Patients may also be counselled to supplement xylometazoline use with a nasal saline product to further aid clearance of nasal mucous.5

  • Family playing in park

    At lower dosages of 0.025%, this compound may be used in infants under 1 year old, with medical advice. 0.05% concentrations may be applied to children between 1 and 11 years old, under adult supervision. Concentrations of 0.1% should only be used in children over the age of 12 into adulthood.1

    For all nasal formulations of xylometazoline hydrochloride, a daily dosage of 3 applications to each nostril should not be exceeded;1 this includes the nasal drops, nasal metered-dose spray, and nasal spray squeeze bottle.

Discover the Otrivin range with xylometazoline hydrochloride

Otrivin Plus Nasal Spray

Otrivin Plus Nasal Spray

Otrivin Plus nasal spray provides symptomatic treatment of the worst nasal symptoms, such as blocked nose, rhinorrhoea and sinus pressure due to common colds6-9.

Key ingredients: 1 ml contains 0,6 mg of ipratropium bromide and 0,5 mg of xylometazoline hydrochloride

Otrivin Adult Nasal Metered-Dose Spray

Otrivin Adult Nasal Metered-Dose Spray

OTRIVIN ADULT Nasal Metered-Dose Spray is specially formulated with a topical vasoconstrictor, which is clinically proven to decongest the nasal passage and improve nasal airflow10 during the common cold, allergic rhinitis, and sinusitis.10

Key ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride.Preservative: 0,011 % m/v benzalkonium chloride.

Otrivin Adult Nasal Drops

Otrivin Adult Nasal Drops

OTRIVIN ADULT Nasal Drops is a fast and long-lasting nasal topical decongestant (xylometazoline), with ingredients to soothe and moisturise dry and irritated nasal passages.11

Key ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride.Preservative: 0,011 % m/v benzalkonium chloride.

Otrivin Menthol Nasal Metered-Dose Spray

Otrivin Menthol Nasal Metered-Dose Spray

OTRIVIN MENTHOL Nasal Metered-Dose Spray contains xylometazoline, which belongs to the group of the alkyl imidazolines and acts on the α-adrenergic receptors. OTRIVIN MENTHOL has vasoconstrictor action, producing decongestion of the nasal and pharyngeal mucosa when administered locally.12

Key Ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride.Preservative: 0,01 % m/v benzalkonium chloride.Excipients: disodium edetate, disodium phosphate dodecahydrate, eucalyptol (Cineole), menthol (Levomenthol), polyoxyl 40 hydrogenated castor oil (Cremophor RH 40), purified water, sodium chloride, sodium dihydrogen phosphate dihydrate, sorbitol 70 % (non-crystallising)

Otrivin Paed Nasal Metered-dose Spray

Otrivin Paed Nasal Metered-dose Spray

OTRIVIN PAED Nasal Metered-dose Spray quick and effective relief of nasal congestion in children, with a concentration of xylometazoline adapted for kids.13

Key ingredients: 1 ml contains 0,5 mg of xylometazoline hydrochloride.Preservative: 0,011 % m/v benzalkonium chloride

Otrivin Paed Nasal Drops

Otrivin Paed Nasal Drops

OTRIVIN PAED Nasal Drops unblocks children’s noses quickly while providing additional soothing and moisturising benefits.14

Key ingredients: 1 ml contains 0,5 mg of xylometazoline hydrochloride.Preservative: 0,011 % m/v benzalkonium chloride.

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