Otrivin overview

Happy joint family standing in a natural landscape

The world’s leading range for symptoms of allergies and colds

Human beings are designed to only breathe through their noses and a healthy nose is needed to do this well. Otrivin understands this and is committed to finding solutions to improve breathing.

The Otrivin range is clinically proven to provide rapid-acting and long-lasting relief of the most bothersome nasal symptoms of allergies and colds.^1–16

Find out more about how Otrivin unblocks and protects your patient’s nose to breathe well.

Otrivin – relief from allergy and cold symptoms^1–16

Nasal symptom relief

Otrivin products relieve bothersome symptoms of allergies and colds, such as nasal congestion, rhinorrhoea, sinus pressure and pain, and sneezing, with long-lasting effects.^1–16

Long-lasting effects

Otrivin products provide long-lasting relief of nasal symptoms with 12 hours of protection.^3-16

Strong scientific evidence

Multiple clinical studies, published in international, peer-reviewed journals, showed the strong efficacy of Otrivin products for relieving allergy and cold symptoms.^3-16

Otrivin – in-depth patient understanding

Nasal symptoms are the most common in allergies and colds

Control the most bothersome symptoms of allergies and colds

Nasal symptoms are the most common symptoms of allergies and colds,^17,18 and includes congestion (a blocked nose), rhinorrhoea (a runny nose), sinus pressure and pain (headaches), and sneezing (blowing your nose often). The Otrivin range offers various options of clinically proven products, to relieve these symptoms.^3-16

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Prevalence of the condition

Are your patients experiencing allergy and cold symptoms?

As many as 1 in 4 people may suffer from allergic disorders in developed countries.¹⁹

More than 90% of the world’s population suffers from nasal symptoms due to the common cold each year.¹⁷
Patients’ daily lives are impacted by nasal symptoms

Nasal symptoms impact quality of life due to:

Breathing difficulties

Discomfort from obstructed breathing due to swelling and mucus.¹⁸

Frequent sneezing

Inconvenience from the frequent need to blow the nose.¹⁸

Low quality sleep

Reduced quality and quantity of sleep.^20,21

Fatigue

Daytime fatigue and poor concentration.²¹

Daily activity impairment

Lost time from work or school.²²

The Otrivin range is specially formulated for clinically proven relief from nasal symptoms of allergies and colds^1-16

Xylometazoline hydrochloride

A strong, topical, alpha-adrenergic agonist that is indicated for the relief of nasal congestion due to colds, hay fever, allergic rhinitis and sinusitis. It may also be used to aid drainage of secretions in affections of the paranasal sinuses.²³

Ipratropium bromide

Ipratropium is an anti-cholinergic agent that reduces watery discharge from the nasal mucosa (rhinorrhoea), and lessens sneezing.⁵

Menthol

Menthol provides a cooling effect by stimulating temperature receptors in the nose, leading to the perception of decongestion, and improved nasal breathing.^30,31

Sorbitol and hypromellose

Sorbitol and hypromellose, found in a nasal spray or drops, soothe and moisturise dry and irritated nasal passageways.^24,35

The Otrivin range offers clinically proven solutions tailored to individual patient needs^1-16

Otrivin Adult Nasal Metered – Dose Spray

OTRIVIN ADULT NASAL Metered- Dose Spray is specially formulated with a topical vasoconstrictor, which is clinically proven to decongest the nasal passage and improve nasal airflow^23,32 during the common cold, allergic rhinitis, and sinusitis.²³

Key ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride. Preservative: 0,011 % m/v benzalkonium chloride.

Otrivin Adult Nasal Drops

OTRIVIN ADULT Nasal Drops is a fast and long-lasting nasal topical decongestant (xylometazoline), with ingredients to soothe and moisturise dry and irritated nasal passages.^7,23-34

Key ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride. Preservative: 0,011 % m/v benzalkonium chloride.

Otrivin Menthol Nasal Metered-Dose Spray

OTRIVIN MENTHOL Nasal Metered-Dose Spray contains xylometazoline, which belongs to the group of the alkyl imidazolines and acts on the α-adrenergic receptors. OTRIVIN MENTHOL has vasoconstrictor action, producing decongestion of the nasal and pharyngeal mucosa when administered locally

Key Ingredients: 1 ml contains 1 mg of xylometazoline hydrochloride.Preservative: 0,01 % m/v benzalkonium chloride. Excipients: disodium edetate, disodium phosphate dodecahydrate, eucalyptol (Cineole), menthol (Levomenthol), polyoxyl 40 hydrogenated castor oil (Cremophor RH 40), purified water, sodium chloride, sodium dihydrogen phosphate dihydrate, sorbitol 70 % (non-crystallising).

Otrivin Plus Nasal Spray

Otrivin Plus nasal spray provides symptomatic treatment of the worst nasal symptoms, such as blocked nose, rhinorrhoea and sinus pressure due to common colds^6-9.

Key ingredients: 1 ml contains 0,6 mg of ipratropium bromide and 0,5 mg of xylometazoline hydrochloride.

Otrivin Paed Nasal Metered-Dose Spray

OTRIVIN PAED Nasal Metered-Dose Spray quick and effective relief of nasal congestion in children, with a concentration of xylometazoline adapted for kids.^23,33

Key ingredients: 1 ml contains 0,5 mg of xylometazoline hydrochloride. Preservative: 0,011 % m/v benzalkonium chloride.

Otrivin Paed Nasal Drops

OTRIVIN PAED Nasal Drops unblocks children’s noses quickly while providing additional soothing and moisturising benefits.^23,36-63

Key ingredients: 1 ml contains 0,5 mg of xylometazoline hydrochloride.Preservative: 0,011 % m/v benzalkonium chloride.

The Otrivin range – the world’s leading allergy and cold products

Colds

Find out more about colds.

Find out more

Educational resources

The resources provided here will give you a deeper understanding of the science behind Haleon’s respiratory health.

Find out more

Patient care resources

Download resources for your patients.

Find out more

Footnotes and references

Mösges R et al. Adv Ther 2017; 34:1850–1858.
Kehrl W et al. Laryngorhinootologie 2003; 82:266–271.
Haye R et al. Rhinology 1993; 31:169–174.
Bernstein DI et al. Clin Exp Allergy 2004; 34:952–957.
Eccles R et al. Am J Rhinol 2007; 21:40–45.
Eccles R et al. Am J Rhinol 2008; 22:491–496.
Hayden FG et al. Ann Intern Med 1996; 125:89–97.
DeWester J et al. Allergy asthma Proc 2003; 24:331–337.
Nathan RA et al. Ann Allergy 1991; 67:332–338.
Banov CH et al. Ann Allergy 1994; 73:240–246.
Dykewicz MS et al. Ann Allergy Asthma Immunol 2003; 91:44–48.
Scadding GK et al. Clin Exp Allergy 1995; 25:737–743.
van As A et al. J Allergy Clin Immunol 1993; 91:1146–1154.
Data on file, GlaxoSmithKline. GSK: Result Summary for Study FNM40184. https://www.gsk-studyregister.com/en/trial-details/?id=FNM40184.12-19-2005.
Ratner PH et al. Allergy asthma Proc 2002; 23:259–263.
Greiner AN et al. Lancet 2011; 378:2112–2122.
Arruda E et al. J Clin Microbiol 1997; 35:2864–2868.
Graf P et al. Expert Opin Pharmacother 2009;10:889–908.
Galli SJ et al. Nature 2008; 454:445‐454.
Wynne JW. Chest 1982; 82:657–658.
Rombaux P et al. Rhinology 2005; 43:242–250.
Worrall G. Can Fam Phys 2007; 53:1735–1736.
Xylometazoline hydrochloride GDS v1.0; 26 Sept 2017; pages 4,12, 23 & 24.
Oxymetazoline hydrochloride Global datasheet; v1.0; 2019; pages 3, 4 & 7.
GSK. Xylometazoline/dexpanthenol GDS, v1.0; 14 Sept 2017.
Dexpanthenol_Otrivin Unblock and Heal_Expert_DA_130818, slide 4.
Burrow A et al. Acta Otolaryngol 1983; 96:157–161.
Papsin B et al. Can Fam Phys 2003; 49:168–173.
GSK Otrivin Seawater IFU; Jun.2018.
Naclerio RM et al. Int J Gen Med 2010; 3:47-57.
Eccles R. Curr Allergy Asthma Rep 2003; 3:210–214.
Cermelli C et al. Curr Microbiol 2008; 56:89‐92.
Care Instructions for Use of Otrivin Saline with Aloe Vera (as per provided aloe vera 1071795 Otrivin Detail Aids Creating PC_C1_A23_GP_AW resource).
Surjushe A et al. Indian J Dermatol 2008; 53:163-6.
Wade A, Weller P. Handbook of Pharmaceutical Excipients. 2nd ed. Washington and London: American Agent and The Pharmaceutical Press; 1994.
Brayfield A. 2014. Martindale: The Complete Drug Reference. 38th edition. London: Pharmaceutical Press.
Pneumatikos I et al. Intensive Care Med 2006; 32:532–537.
GSK. Global Data Sheet of Xylometazoline hydrochloride/ipratropium bromide, 2019.
Children’s FLONASE® Allergy Relief Label.
Acute Sinusitis. Cleveland Clinic 2018 Available at: http://my.clevelandclinic.org/services/head-neck/diseases-conditions/hic-acute-sinusitis. (Accessed January 2020).
Gwaltney JM. Am J Med 2002; 112:13S-18S.
Eskiizmir G et al. Eur J Clin Pharmacol 2011; 67:19–23.
Peier AM et al. Cell 2002; 108:705–715.
Bende M et al. J Laryngol Otol 1986; 100:285-8.
Pevernagie D et al. Eur Respir J 2000; 15:996-1000.
GSK Breathe Right Nasal Strips core IFU v2.0; 07 Nov 2019.
Clarke RW et al. Clin Otolaryngol Allied Sci 1995; 20:72–73.
Eccles R. Over the counter medicines for colds. In: Eccles R, Weber O, editors. Common cold. Basel, Switzerland: Birkhauser Verlag; 2009;249–273.
GSK. Global Data Sheet of Otrivin Baby Nasal Aspirator (Soft Nozzle), 2018.
GSK. Global Data Sheet of Otrivin Baby Natural Monodose / Otrisal Monodose, 2018.
Otrivin Existing Range Overview, September 2019; page 3.
GSK. Global Data Sheet of Otrivin Natural Plus with Eucalyptus, 2019.
GSK. Global Data Sheet of Otrivin* Natural Plus, 2019.
GSK. Global Data Sheet of Otrivin Natural / Otrivin Saline Sea Water, 2018.
GSK. Global Data Sheet of Otrivin Natural with Aloe Vera / Otrivin Sea Water with Aloe Vera, 2018.
Meadows TP. Cosmetics and Toiletries 1980; 95:51-56.
Boston M et al. Arch Otolaryngol Head Neck Surg 2003; 129:660–664.
Otrivin Menthol Nasal Metered-Dose Spray patient leaflet. January 2019.
Otrivin Adult Nasal Metered- Dose Spray Patient Leaflet. March 2019
Otrivin Adult Nasal Drops Patient Leaflet. March 2019
Otrivin Paed Nasal Metered- Dose Spray Patient Leaflet. March 2019.
Otrivin Paed Nasal Drops Patient Leaflet. March 2019.
OTRIVIN PLUS Nasal Metered-dose Spray (Solution) package insert February 2021.

S1 OTRIVIN ADULT Drops. Each 1 ml contains 1 mg of xylometazoline hydrochloride. Preservative: benzalkonium chloride 0.01 % m/v. Reg. no.: H/16.1/1382.

S1 OTRIVIN ADULT Nasal Metered-dose Spray. Each 1 ml contains 1 mg of xylometazoline hydrochloride. Preservative: benzalkonium chloride 0.01 % m/v. Reg. no.: H/16.1/1382.

S2 OTRIVIN PLUS Nasal Metered-dose Spray (Solution). Each 1 ml contains 0,6 mg of ipratropium bromide and 0,5 mg of xylometazoline hydrochloride. (Preservative-free). Reg. no.: 46/16.1/0819.

S1 OTRIVIN MENTHOL Nasal Metered-dose Spray. Each 1 ml contains 1 mg of xylometazoline hydrochloride. Preservative: benzalkonium chloride 0.01% m/v. Reg. no.: 31/16.1/0319.

S1 OTRIVIN PAED Drops. Each 1 ml contains 0,5 mg of xylometazoline hydrochloride. Preservative: benzalkonium chloride 0.01 % m/v. Reg. no.: H/16.1/1381.

S1 OTRIVIN PAED Nasal Metered-dose Spray. Each 1 ml contains 0, 5 mg of xylometazoline hydrochloride. Preservative: Benzalkonium chloride 0.01 % m/v. Reg. no.: H/16.1/1381.

Applicant: Haleon South Africa (Pty) Ltd. 11 Hawkins Avenue, Epping Industria 1, Cape Town, 7450

Company reg. no.: 2014/173930/07. For full prescribing information refer to the professional information approved by the medicines regulatory authority.

Always read label prior to use.

For any further information, including safety and adverse reactions, please contact the Haleon Hotline on 0800 007 018 or mystory.za@haleon.com.

Trade Marks are owned by or licensed to the Haleon group of companies.

This site is intended for RSA healthcare professionals only.

© 2024 Haleon group of companies or its licensor. All rights reserved. Trademarks are owned by or licensed to the Haleon group of companies. This website is operated by Haleon South Africa (Pty) Ltd. 17 Muswell Road South, Block D, Wedgefield, Phase 2, Bryanston, Johannesburg, 2191, South Africa. Reg. No: 2014/173930/07. For any further information, including Human Safety Information (Adverse events/Product Quality Complaints) please contact the Haleon on 0800 007 018 or mystory.za@haleon.com. Always read the label, the leaflet or carton for full use instructions before use.

PM-ZA-NOBR-20-00013

PM-ZA-OTRI-21-00044Date of Preparation: October 2024

Otrivin overview

The world’s leading range for symptoms of allergies and colds

Otrivin – relief from allergy and cold symptoms1–16

Nasal symptom relief

Long-lasting effects

Strong scientific evidence

Otrivin – in-depth patient understanding

Control the most bothersome symptoms of allergies and colds

Are your patients experiencing allergy and cold symptoms?

Nasal symptoms impact quality of life due to:

Breathing difficulties

Frequent sneezing

Low quality sleep

Fatigue

Daily activity impairment

The Otrivin range is specially formulated for clinically proven relief from nasal symptoms of allergies and colds1-16

The Otrivin range offers clinically proven solutions tailored to individual patient needs1-16

The Otrivin range – the world’s leading allergy and cold products

Colds

Educational resources

Patient care resources

Footnotes and references

Otrivin – relief from allergy and cold symptoms^1–16

The Otrivin range is specially formulated for clinically proven relief from nasal symptoms of allergies and colds^1-16

The Otrivin range offers clinically proven solutions tailored to individual patient needs^1-16