Nexium 24HR

Nexium package shots

All-day and all-night heartburn protection

Help patients suffering from frequent heartburn (2 or more days per week) take back control of their symptoms with once-daily, single-pill dosing of Nexium 24HR for 14 consecutive days. Nexium 24HR is a proton pump inhibitor (PPI) that works by blocking acid at the source for 24-hour frequent heartburn protection. Keep reading to learn more about the science behind Nexium 24HR and access new downloadable resources designed for healthcare professionals like you.

Unlock the power of the purple pill

All-day, all-night protection icon

24-Hour Relief from Heartburn

Nexium 24HR works 2x as long as histamine blockers (H2s) by stopping stomach acid before it starts. In clinical trials, Nexium 24HR has been shown to treat frequent heartburn for up to 24 hours when taken once each morning before eating for 14 consecutive days. Nexium 24HR is available in convenient capsule, ClearMini and tablet options, as well as an “Easy-Open Cap” capsule bottle that was recognized by the Arthritis Foundation® for ease of use.

Stop acid before it starts icon

Grounded in Science

Esomeprazole is a PPI that suppresses gastric acid secretion by specific inhibition of H+/K+ ATPase in the gastric parietal cell. The S-isomer of omeprazole is protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

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The Nexium 24HR Promise

We take the power of the purple pill to heart. So much so that we’ll give your patients their money back if they’re not completely satisfied with Nexium 24HR following your recommendation. To submit a guarantee request, patients can call one of our Consumer Relations Associates (CRA) at 1-800-245-1040. See details

Stronger, longer acid control vs omeprazole 20 mg1-2^†‡§

  • Nexium 24HR—the most powerful over-the-counter acid blocker available.1-2^†‡§

    Nexium 24HR research findings

    Nexium 24HR and Prilosec OTC are both over-the-counter PPIs, but they have different active ingredients. Omeprazole 20 mg (equivalent to Prilosec OTC)^ is a racemic mixture, which is a compound composed of two isomers: the S- and R-isomers. Esomeprazole contains only the S-isomer, which is more bioavailable than the racemic mixture, and therefore delivers 80% more acid blockers to the source compared to omeprazole 20 mg (equivalent to Prilosec OTC).^ By having only the S-isomer, esomeprazole—the active ingredient in Nexium 24HR—is more effective in suppressing acid.

    With more consistent acid control for a longer duration of time vs. omeprazole 20 mg,1^ Nexium 24HR can help your patients get 24 hours of relief from frequent heartburn.

Recommend Nexium 24HR

You can recommend Nexium 24HR with confidence.

Patients to consider recommending Nexium 24HR include—

Rx patients who:

  • Can’t afford the copay for their Rx PPI
  • Have had a change in formulary coverage and whose PPI is no longer covered

Patients who are:

  • New to OTCs for frequent heartburn
  • Not getting adequate relief with antacids or H2 blocker medications
  • OTC PPI users who are dissatisfied with their current treatment

Nexium 24HR Products

Nexium 24HR Capsules


24-hour protection in a capsule form.

Nexium 24HR ClearMinisTM


Our mini capsule contains all the power of Nexium 24HR frequent heartburn protection in a 38% smaller pill.

Nexium 24HR Tablets


24-hour protection in an easy-to-swallow tablet.

Nexium 24HR Easy Open Cap

Easy Open Cap

Easy-open cap is recognized by the Arthritis Foundation for ease of use.

Related Resources



Download our updated FAQ document designed for HCPs.

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Patient FAQs

Patient FAQs

Download our patient FAQ document for your practice.

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Nexium 24HR PharmAssist Kit

PharmAssist Kit

Download our product information kit created with the unique needs of pharmacy teams in mind.

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