Advil dual action frequently asked questions

A resource to help answer common questions about Advil^® DUAL ACTION.

Help further uncover the most frequently asked questions about ibuprofen.

Patients are often concerned with many aspects of taking new medication in order to deal with their pain. Advil^® DUAL ACTION can provide them powerful pain relief, while you provide them ease of mind.

Understanding what makes Advil^® DUAL ACTION different from regular Advil^® can help you identify which treatment is most effective for your patient’s pain. In Advil Dual Action the combination of two active ingredients – ibuprofen and acetaminophen work to fight the pain at its physical core while also signaling to the central nervous system. Understanding how to treat pain, begins with understanding how to communicate with the patient.

The following questions and answers will provide a consumer friendly way of addressing all your patients' concerns. Download our Advil^® DUAL ACTION FAQ PDF for your office!

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What is Advil® DUAL ACTION and how is it different from regular Advil®?

Advil® DUAL ACTION is a combination of ibuprofen (125 mg) and acetaminophen (250 mg)—two distinct mechanisms of action (MOA) working together to fight pain. Regular Advil® features ibuprofen (200 mg) as a stand-alone painkiller.
How does Advil® DUAL ACTION work?

Advil® DUAL ACTION combines the pain-fighting power of its two active ingredients—ibuprofen and acetaminophen. Ibuprofen, a traditional NSAID, decreases the synthesis of pain- and inflammation promoting prostaglandins via nonselective inhibition of COX-1 and COX-2. Acetaminophen, a non-NSAID analgesic, is believed to exert its effects via central nervous system COX inhibition and activation of central serotonergic pathways.^1,2
How does Advil® DUAL ACTION compare to each ingredient used as monotherapy?
In a clinical study, Advil® DUAL ACTION provided powerful pain fighting across primary and secondary end points than either ibuprofen 250 mg or acetaminophen 650 mg alone.³

Advil® DUAL ACTION had a fast onset of action³

Advil® DUAL ACTION had an 8-hour duration of action³
Are there any new side effects or safety concerns with Advil® DUAL ACTION?

Advil® DUAL ACTION combines two of the most widely used analgesics in the world, both with established efficacy and safety profiles. No new safety concerns were identified with Advil® DUAL ACTION compared with each ingredient alone. Refer to the Drug Facts label for specific warnings associated with acetaminophen and NSAID use.
How common is it to combine acetaminophen and ibuprofen for pain relief?

In a recent survey, 31% of dentists reported that they are already recommending the monocomponents together. Now HCPs can recommend both ingredients in one pill.⁴ Advil® DUAL ACTION is the first FDA-approved ibuprofen/acetaminophen combination.
What is the dosing of Advil® DUAL ACTION and how does that compare to single ingredient ibuprofen and or acetaminophen?

Each Advil® DUAL ACTION tablet contains 125 mg of ibuprofen and 250 mg of acetaminophen and can be taken as 2 tablets every 8 hours, for a total of 6 tablets per day. Individually ibuprofen and acetaminophen usually need to be dosed every 4-6 hours.^5,6 Total maximum daily dose comparison between Advil® DUAL ACTION and each ingredient alone:
Why does Advil® DUAL ACTION work for 8 hours?

Advil® DUAL ACTION lasts 8 hours as a result of the two different modes of action working in concert. The two differing mechanisms make for a prolonged duration of pain-fighting power.
Advil® DUAL ACTION

Advil® DUAL ACTION can be used to temporarily relieve minor aches and pains due to headache, toothache, menstrual cramps, backache, muscular aches, and the minor pain of arthritis.
Where can I find additional information on NSAIDS regarding coronavirus?

You can find information about NSAID use for coronavirus symptoms at gskhealthpartner.com/covid19.
Why isn’t Advil® DUAL ACTION indicated for fever reduction when both ibuprofen and acetaminophen are proven antipyretics?

In order for the FDA to approve an indication for a combination product, the combination product needs to outperform both individual components. While both ibuprofen and acetaminophen are proven antipyretics, the combination did not provide statistical significance over each ingredient alone in clinical studies.
How will Advil® DUAL ACTION be supplied and how much will it cost?

See table for sizing and approximate pricing for Advil® DUAL ACTION. Please note that the average retail price will vary based on retailer.

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A resource to help answer common questions about Advil® DUAL ACTION.

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References

A resource to help answer common questions about Advil^® DUAL ACTION.