Caffeine formulations

Scientist in lab

Caffeine is an analgesic adjuvant for paracetamol,2-4

The *analgesic adjuvant effects of caffeine are proposed to result from several mechanisms:8,9

  • Blockade of the peripheral pronociceptive actions of adenosine
  • Activation of central noradrenergic pathways that constitute an endogenous pain suppressing system
  • Central nervous system stimulation with a consequent modulation of the affective component of pain

*A minimum concentration of 65mg caffeine in a single dose is required to have a statistically significant adjuvant effect.

Panadol C&F formulations contain 25mg per single dose. Coffee and tea have an estimated caffeine content of 0 – 96mg/237ml and 2-47mg/237ml respectively depending on the variant.

Caffeine enhances the analgesic effect of paracetamol4

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    Increases the effectiveness of paracetamol

    Paracetamol-caffeine combinations have been shown to provide superior pain relief compared to paracetamol alone.4

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    Oral Administration

    After oral administration, caffeine is completely and rapidly absorbed from the gastrointestinal tract with peak concentrations occurring between 5 and 120 minutes depending on the dose, health status, and co-medications in fasted subjects.5

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    The influence of caffeine (60 mg) on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) was studied in 10 healthy male human volunteers in a complete cross‐over design. High‐performance liquid chromatography (HPLC) was used to analyse serum drug concentrations.1

    Caffeine caused a highly significant (p< 0.01) increase in AUC and AUMC, a significant (p<0.05) increase in Cmax, and a significant (p<0.05) decrease in clearance (Cl/F) of acetaminophen.1

    Study summary

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    Adverse reactions reported for caffeine include dizziness, headache, insomnia, restlessness, anxiety, irritability, nervousness, heart palpitation, and gastrointestinal disturbances.

    Note that combining caffeine-containing medicinal products with dietary caffeine intake may increase the potential for caffeine-related adverse effects.4

Discover the Panadol Cold & Flu Day with caffeine

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Panadol Cold & Flu Day

Panadol Cold & Flu Day contains caffeine. In addition, this product also contains Paracetamol and Phenylephrine.7

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