Crocin for children

Go To

Crocin for children pack shot

Tough** on fever and pain,1 gentle 1,3¶ on the child†

Crocin for children contains paracetamol, which is recommended as first-line treatment for fever and mild-to-moderate pain in children.2-4 It starts to relieve fever within 15 minutes of dosing.1,5-7

Chart adapted from the World Health Organization guidelines on fever management in children

The World Health Organization guidelines on fever management state that when a child presents with fever, danger signs should be looked for. These include an inability to drink, persistent vomiting, convulsions, lethargy or unconsciousness, stridor in a calm child or severe malnutrition. If these signs are present, the patient must be referred immediately for specialist management.8

The symptomatic fever, associated with distress due to non-specific respiratory infections, diarrhoea and other infections, is managed with paracetamol.2

Chart showing reduction of temperature after paracetamol. Adapted from Wong et al. 2001.

This was a randomised, double-blind multicentre trial involving febrile children aged 6 months to 6 years who were given a dose of paracetamol (acetaminophen) 12 mg/kg (n=210). A downward slope in temperature was seen at the 15-minute time point. Maximal rate of temperature reduction was reached at 60 minutes in the paracetamol group.6

As effective as ibuprofen at doses of 10 mg/kg9

Chart showing the reduction of temperature in children given paracetamol 10 mg/kg or ibuprofen 10 mg/kg. Adapted from Vauzelle et al. 1997

This was a randomised, double blind, multicentre trial with 116 children aged 4.1 years (± 2.6 years) with a fever related to an infectious disease and a mean baseline temperature of 39°C (± 0.5°C), who were treated with either single doses of ibuprofen 10.3 mg/kg (± 1.9 mg/kg) or paracetamol 9.8 mg/kg (± 1.9 mg/kg). The children’s rectal temperature was regularly monitored for 6 hours. Tmax is the time that elapsed between first dose of drug administration and lowest temperature observed between the 0-6 hours.9

When given to children with fever, both paracetamol 10 mg/kg and ibuprofen 10 mg/kg were similar in reduction of temperature in the time between dosing and achieving lowest temperature during 0-6 hours.9

Chart showing the reduction of temperature in children given paracetamol 15 mg/kg or ibuprofen 10 mg/kg. Adapted from Autret-Leca et al. 2007

A randomised, single-dose, double-blind study in children from 3 months to 12 years old (N = 301) with non-serious fever received either paracetamol 15 mg/kg or ibuprofen 10 mg/kg. Mean temperature in both groups were 38.9°C at baseline. Primary outcome was tympanic temperature reduction over the following 8 hours post first dose administration.

Both paracetamol 15 mg/kg and ibuprofen 10 mg/kg had similar (not significant) reductions in temperature. The mean area under the curve (AUC) was -7.66°C and -7.77°C, respectively.10

Effective as pain-relief in children11

Chart showing significant pain relief from paracetamol vs. placebo as assessed by children and their parents. Adapted from Schactel et al. 1993.

This was a randomised, single-dose, double-blind, placebo-controlled study in children aged 2-12 years with acute sore throat treated with paracetamol 15 mg/kg, ibuprofen 10 mg/kg or placebo. Paracetamol showed significant pain relief vs. placebo from 1-hour post dose, which was sustained until 4 hours after dosing based on the children’s assessment of their pain.The parents’ assessment of changes in pain intensity seen in their children reflected the same.11

An unsurpassed tolerability profile among children’s over-the counter analgesics/antipyretics3,12

Happy child with his mother

When compared to non-steroidal anti-inflammatory drugs (NSAIDs) e.g. ibuprofen, paracetamol is preferred because it is gentle on tiny tummies,1,3 has a lower risk of bleeding complications in certain vector-borne diseases like dengue2 may be suitable for children with dehydration12 and does not interact with as many other medicines like ibuprofen does.2

In a literature review of 23 clinical studies of paracetamol involving children, the safety data showed that paracetamol had comparable safety to ibuprofen and ketoprofen in short-term treatment of fever.3

Crocin for children comes in different formulations

Crocin drops pack shot

Children’s Crocin 1 month-2 years colourfree drops

Crocin Drops are an effective treatment for pain associated with kids.

Crocin 120 pack shot

Crocin 120 1-5 years suspension

Crocin 120 contains paracetamol which helps relieve pain caused by teething, immunization, earache, headache, cold and flu symptoms in children. It gets to work in just 15 minutes.

Crocin 240 pack shot

Crocin 240 5-12 years suspension

Crocin 240 contains paracetamol which helps relieve pain caused by teething, immunization, earache, headache, cold and flu symptoms in children. It gets to work in just 15 minutes.

Crocin for children product details

  • Ingredients: Paracetamol 100 mg/ml.

    Also includes excipients: macrogol 400, glycerol, saccharin sodium, sodium chloride, vanilla 054468 T7, soium citrate, citric acid – anhydrous, methyl hydroybenzoate, cherry 51849 T7, propyl hydroxybenzoate and water – purified.

    Special warnings and precautions for use

    Contains paracetamol. Do no use with any other paracetamol-containing products. The concomitant use with other products containing paracetamol may lead to an overdose.

    Paracetamol overdose may cause liver failure which may require liver transplant or lead to death.

    Underlying liver disease increases the risk of paracetamol-related liver damage, Patients who have been diagnosed with liver or kidney impairment must seek medical advice before taking this medication.

    Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index, are chronic heavy users of alcohol or have sepsis.

    In patients with glutathione-depleted states the use of paracetamol may increase the risk of metabolic acidosis.

    If symptoms persist, medical advice must be sought.

    Paracetamol should be used with caution in patients with:

    • liver function: underlying liver disease increases the risk of paracetamol-related liver damage
    • impaired kidney function: administration of paracetamol to patients with moderate to severe renal impairment may result in accumulation of paracetamol conjugates

    Crocin for children 1 month-2 years colourfree drops contain methyl and propyl hydroxybenzoates that may cause allergic reactions (possibly delayed).

    Contraindication:

    Hypersensitivity to paracetamol or any of the excipients.

  • Ingredients: Paracetamol 24 mg/ml

    Also includes excipients: maltitol solution, sorbitol solution (70 per cent) (crystallising), water – purified, xanthan gum, nipasept sodium, strawberry flavour L10055, imitation candied sugar 510155U, malic acid and citric acid – anhydrous.

    Special warnings and precautions for use

    Contains paracetamol. Do no use with any other paracetamol-containing products. The concomitant use with other products containing paracetamol may lead to an overdose.

    Paracetamol overdose may cause liver failure which may require liver transplant or lead to death.

    Underlying liver disease increases the risk of paracetamol-related liver damage, Patients who have been diagnosed with liver or kidney impairment must seek medical advice before taking this medication.

    Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index, are chronic heavy users of alcohol or have sepsis.

    In patients with glutathione-depleted states the use of paracetamol may increase the risk of metabolic acidosis.

    If symptoms persist, medical advice must be sought.

    Paracetamol should be used with caution in patients with:

    • liver function: underlying liver disease increases the risk of paracetamol-related liver damage
    • impaired kidney function: administration of paracetamol to patients with moderate to severe renal impairment may result in accumulation of paracetamol conjugates

    Crocin 120 colourfree suspension 1 – 5 Years contains maltitol and sorbitol liquid. Patients with rare hereditary problems of fructose intolerance should not take this medicine. Contains 135 mg/mL sorbitol (old formulation), 115 mg/mL sorbitol (new formulation).

    Contraindication:

    Hypersensitivity to paracetamol or any of the excipients.

    Side effects:

    Body system Undesirable effect
    Blood and lymphatic system disorders Thrombocytopenia
    Immune system disorders

    Anaphylaxis

    Cutaneous hypersensitivity reactions including among others, skin rashes, angioedema, Steven Johnson syndrome and toxic epidermal necrolysis
    Respiratory, thoracic and mediastinal disorders Bronchospasm in patients sensitive to aspirin and other NSAIDs
    Hepatobiliary disorders Hepatic dysfunction

  • Ingredients: Paracetamol 48 mg/ml

    Also includes excipients: maltitol solution, sorbitol solution (70 per cent) (crystallising), avicel RC – 591, xanthan gum, orange flavour LM-908, artifical candied sugar flavour 510352A, sodium methyl hydroxybenzoate, saccharin sodium, citric acid – anhydrous, sodium propyl hydroxybenzoate, polysorbate 80 and water – purified.

    Special warnings and precautions for use

    Contains paracetamol. Do no use with any other paracetamol-containing products. The concomitant use with other products containing paracetamol may lead to an overdose.

    Paracetamol overdose may cause liver failure which may require liver transplant or lead to death.

    Underlying liver disease increases the risk of paracetamol-related liver damage, Patients who have been diagnosed with liver or kidney impairment must seek medical advice before taking this medication.

    Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index, are chronic heavy users of alcohol or have sepsis.

    In patients with glutathione-depleted states the use of paracetamol may increase the risk of metabolic acidosis.

    If symptoms persist, medical advice must be sought.

    Paracetamol should be used with caution in patients with:

    • liver function: underlying liver disease increases the risk of paracetamol-related liver damage
    • impaired kidney function: administration of paracetamol to patients with moderate to severe renal impairment may result in accumulation of paracetamol conjugates

    Each Crocin 240 colourfree suspension 5 – 12 years contains maltitol and sorbitol liquid. Patients with rare hereditary problems of fructose intolerance should not take this medicine. Contains 371 mg/mL sorbitol (old and new formulations).

    Contraindication:

    Hypersensitivity to paracetamol or any of the excipients.

    Side effects:

    Body system Undesirable effect
    Blood and lymphatic system disorders Anaphylaxis
    Immune system disorders Cutaneous hypersensitivity reactions including among others, skin rashes, angioedema, Steven Johnson syndrome and toxic epidermal necrolysis
    Respiratory, thoracic and mediastinal disorders Bronchospasm in patients sensitive to aspirin and other NSAIDs
    Hepatobiliary disorders Hepatic dysfunction

Learn more

Patient in consultation with pharmacist

Managing children’s fever and pain

Tailor made for pharmacists, this tool is an excellent guide to help you manage children with fever or pain.

Get it now

Mother with baby

When to refer children with fever

Learn more about “red-flag” symptoms when children present with fever.

Learn more

Paracetamol chemical structure

The science of paracetamol

Learn more about paracetamol – the basics, its mechanism of action and more.

Learn more