The revolutionary Optizorb technology allows Crocin Advance to begin dissolving in 5 minutes1 and start to relieve pain within 15 minutes with 2 tablets (1000 mg dose).3 May be suitable for special populations including those with cardiovascular disease,4 heart conditions,5-7 hypertension,6 the elderly8 and diabetics.9
Crocin Advance gets to work in 5 minutes1
Gamma scintigraphic images (scinitigraphy is a form of radio-imaging or scanning that involves injecting a radioisotope that emits gamma rays, into a patient’s vein, which is captured as images)10 of the stomach showed that Crocin Advance with Optizorb technology disintegrates 25% faster than standard paracetamol tablets (within 5 minutes).1
From 20 minutes, it is fully disintegrated and available for absorption from the intestine, while standard paracetamol tablets have yet to leave the stomach.1
Crocin Advance absorbs twice as fast11 †
This was a pharmacokinetic study of 76 healthy adults of replicate dosing of Crocin Advance or standard paracetamol tablets (1000 mg dose) administered on 4 separate days.11 The average concentration of paracetamol in plasma at 10, 20 and 30 minutes for Crocin Advance was 1.62; 3.26; 4.93 vs. 0.69; 1.8; 2.82 for standard paracetamol tablets. This means that the concentration of paracetamol at 10, 20 and 30 minutes in subjects taking Crocin Advance was 134%, 81% and 75% higher than those that ingested standard paracetamol tablets.11
Recommend Crocin Advance for fast and effective relief
Disintegrates faster and available for absorption quicker1* to provide pain relief.
Each table contains paracetamol 500 mg.
Special warnings and precautions for use
Care is advised in the administration of paracetamol to patients with renal or hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease.
Do not exceed the stated dose.
Patients should be advised to consult their doctor if their headaches become persistent.
Patient should be advised not to take other paracetamol-containing products concurrently.
Patients should be advised to consult a doctor if they suffer from non-serious arthritis and need to take painkillers every day.
Keep out of the reach and sight of children.
Immediate medical advice should be sought in the event of an overdose, even if you feel well, because of the risk of delayed, serious liver damage.
Hypersensitivity to paracetamol or any of the other constituents.
Body system Undesirable effect Frequency Blood and lymphatic system disorders Thrombocytopenia Very rare Immune system disorders
Cutaneous hypersensitivity reactions including among others, skin rashes, angioedema and Steven Johnson syndrome and toxic epidermal necrolysis
Very rare Respiratory, thoracic and mediastinal disorders Bronchospasm in patients sensitive to aspirin and other NSAIDs Very rare Hepatobiliary disorders Hepatic dysfunction Very rare