Panmigrol Migraine Pain Relief 250 mg /250 mg /65 mg film coated tablets (aspirin, paracetamol, caffeine)

Panmigrol Tablets pack shot

Powerful migraine relief

The powerful triple action* of paracetamol, acetylsalicylic acid (aspirin) and caffeine in Panmigrol work together to help combat migraine.1 It has been shown to be more effective than 50mg sumatriptan and standard ibuprofen tablets.2

*blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect.

Figure showing Panmigrol active ingredients

Each component in Panmigrol Tablets works to counteract the mechanisms thought to play a role in migraine.3-5

  • Acetylsalicylic acid (aspirin) and Paracetamol act as peripheral and centrally acting analgesics whose effects are mediated by overlapping but distinct actions.6
  • Caffeine acts as an analgesic adjuvant, enhancing the pain relief effects.7
Chart showing efficacy of Panmigrol Tablets compared to placebo

Quickly relieves migraine pain for lasting relief*

Panmigrol Tablets reduce migraine pain to mild or none in significantly more patients from 30 minutes vs placebo and lasts up to 6 hours.1

*for up to 6 hours.

Chart showing efficacy of Panmigrol Tablets compared to placebo

Significantly improves migraine associated symptoms1

Panmigrol Tablets significantly improved pain and migraine associated symptoms such as nausea, sensitivity to light and sensitivity to sound.1

Chart showing efficacy of Panmigrol Tablets compared to sumatriptan 50mg and placebo

More effective pain relief than 50mg sumatriptan

The combination of ingredients in Panmigrol was shown to be significantly more effective than sumatriptan in the early treatment of migraine.2

This result was demonstrated for the primary efficacy variable (change in pain intensity after 4 hours) and for multiple secondary efficacy variables, including pain relief, pain intensity reduction, response, sustained response, relief of associated symptoms, use of rescue medication, disability relief, and global assessments of effectiveness.2

What can Panmigrol do for Rebecca?

Patient with migraine holding forehead

Rebecca needs migraine relief

When it attacks, Rebecca gets a throbbing headache on the right side, feels sick and finds noise and light hard to bear. She’s tired and stressed, waiting for the next migraine attack. All she wanted was to enjoy a normal life, but with sleepless nights, the migraines are getting bothersome.

Rebecca wants something that is effective to help manage her migraine symptoms.

Panmigrol contains a powerful triple action* combination of active ingredients to help Rebecca manage her migraine pain. It not only relieves the pain associated with migraines, it also helps tackle other migraine symptoms including photo- and phonophobia and nausea, as well as migraines occurring with or without aura.

Panmigrol delivers more effective migraine relief than 50mg sumatriptan and standard ibuprofen tablets.

*blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect.

Recommend Panmigrol to combat migraine headaches

Panmigrol Tablets pack shot

Panmigrol Tablets

The powerful triple action* combination of paracetamol, acetylsalicylic acid (aspirin) and caffeine working together to help combat migraine with or without aura.1

*blocks pain signals, elevates your pain threshold, and uses caffeine to enhance the pain relief effect.

Panmigrol Tablets product information

  • Product Information

    Panmigrol Migraine Pain Relief 250 mg /250 mg /65 mg film coated tablets, Panmigrol Migraine and Headache Relief 250 mg /250 mg /65 mg film coated tablets (acetylsalicylic acid, paracetamol, caffeine). Indications: Acute treatment of headache and of migraine attacks with or without aura. Dosage and administration: Adults (18 years and over) only. Headache: 1 tablet; if needed an additional tablet can be taken. Intense pain: 2 tablets. If needed an additional 2 tablets can be taken with 4 to 6 hours between doses. For episodic use, up to 4 days for headache. Migraine: Take 2 tablets when symptoms appear. If needed an additional 2 tablets can be taken, with 4 to 6 hours between doses. Intended for episodic use, up to 3 days for migraine. Maximum 6 tablets in 24 hours. Drink a full glass of water with each dose. Not recommended for use in children under 18 years. Contraindications: Hypersensitivity to the active ingredients or excipients. Patients in whom attacks of asthma, bronchospasm, angioedema, urticaria, or acute rhinitis are precipitated by aspirin or other NSAIDs. Active gastric or intestinal ulcer, gastrointestinal bleeding, or perforation and in patients with a history of peptic ulceration. Haemophilia or other haemorrhagic disorders. Severe cardiac, hepatic, or renal impairment or failure. Intake of more than 15 mg methotrexate per week. Third trimester of pregnancy. Precautions: Do not use with systemic NSAIDs, anticoagulants, medicines that inhibit platelet aggregation, aspirin-containing or paracetamol-containing products or alcohol; if vomiting occurs with > 20% of migraines or bedrest is needed with >50% of migraine attacks; for more than 10 days per month for more than 3 months. Discontinue use immediately in suspected medication overuse headaches, gastrointestinal bleeds, or ulceration. GI bleeds / ulceration generally have more serious consequences in the elderly. Use special precaution in those with bronchial asthma, seasonal allergic rhinitis, nasal polyps, chronic obstructive pulmonary disease, or chronic infection of the respiratory tract. Use caution in undiagnosed migraineurs, or those with atypical symptoms, exclude other neurological conditions; patients with dehydration, gout, reduced uric acid excretion, congestive heart failure, impaired renal or hepatic function/disease, those with depleted glutathione levels e.g. severely malnourished, anorexic, low body mass index, sepsis, uncontrolled hypertension, severe glucose 6-phosphate dehydrogenase deficiency, diabetes mellitus, defects of haemostasis (monitoring is advised), metrorrhagia, menorrhagia, alcohol dependence, hyperthyroidism (may interfere with thyroid tests), arrhythmia. May mask the signs and symptoms of infection, increase bleeding tendency during/after surgery. Caution, regarding paracetamol, if used at therapeutic doses for a prolonged period or administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism). If suspected, discontinue use promptly and monitor closely, including measurement of urinary 5-oxoproline. Also use with caution if used with other potentially hepatotoxic medicinal products or products that induce liver microsomal enzymes. Should not be given to children and adolescents aged under 18 years unless specifically indicated because there is a possible association between acetylsalicylic acid and Reye’s syndrome. Limit use of caffeine containing products. If no migraine relief from first 2-tablet dose, seek advice from physician. Contains 0.03mg benzoic acid per tablet. Side effects: Common: Nervousness, dizziness, nausea, abdominal discomfort. For full side effects please see summary of product characteristics. Legal category and RRP (excl. VAT): GSL: £3.13 P: £5.21 Product licence number: GSL: PL 44673/0229, P: PL 44673/0231 Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, United Kingdom. Text prepared: Feb 2025.

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