Panadol 500 mg capsules, soft (Paracetamol) Indications: For the treatment of most painful and febrile conditions, including headache, migraine, backache, toothache, rheumatic pain and dysmenorrhoea as well as for relief of the symptoms of colds, influenza and sore throat. Symptomatic relief of pain due to non-serious arthritis. Dosage and administration: Adults and children, 16 years and over: One or Two capsules up to four times daily as required. Max. 8 capsules in 24 hours. Children 10-15 years: One tablet four times daily as required. Max. 4 tablets in 24 hours. Children under 10 years: Not recommended. Take with enough water. Stop treatment if pain lasts longer than 5 days or fever lasts longer than 3 days and seek doctor’s advice. Doses should not be repeated more frequently than every 4 hours. Contraindications: Known hypersensitivity to any of the ingredients. Warnings and Precautions: Do not use long-term or frequently except under medical supervision. Long-term use (> 3 months) of analgesics with intake every other day or more frequently, headache can occur or become worse. Do not use with any other paracetamol-containing products. Reconsider treatment in the case of a high fever, symptoms of secondary infection or the persistence of symptoms. Seek immediate medical advice if several daily doses taken at once and patient feels unwell. Use with caution in those with renal or hepatic impairment, acute hepatitis, the concomitant administration of medicinal products which have an influence on hepatic function, glucose-6-phosphate dehydrogenase deficiency, haemolytic anaemia, alcohol abuse, chronic alcoholism, dehydration and chronic malnutrition, asthmatics who are sensitive to acetylsalicylic. For children a treatment of 60 mg/kg/day of paracetamol combined with another antipyretic is not allowed, unless due to a lack of efficacy. Use with caution in patients with glutathione depletion due to metabolic deficiencies. Caution, regarding paracetamol, if used at therapeutic doses for a prolonged period or administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism). If suspected, discontinue use promptly and monitor closely, including measurement of urinary 5-oxoproline. Patients with non-serious arthritis who need to take painkillers every day should consult a doctor. Contains 108mg sorbitol per capsule. Patients with rare hereditary problems of fructose intolerance should seek medical advice before taking this medicine. Side effects: Very rare: Thrombocytopenia, agranulocytosis, anaphylaxis, cutaneous hypersensitivity reactions including skin rash, and angioedema. Bronchospasm and hepatic dysfunction. Not known: high anion gap metabolic acidosis due to pyroglutamic acidosis in patients with risk factors. Legal category and RRP (excl. VAT): GSL: 16s £3.96 Product licence number: PL 44673/0233 Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, United Kingdom. Text prepared: Jan 2025.
