Efficacy Comparison of Diclofenac Gel and Acetaminophen for Knee OA

Diclofenac Gel for Knee OA Study Summary

Download our poster to learn more about how treating knee OA with diclofenac sodium gel (DSG 1%) achieved clinically and statistically significant improvements in pain, function and stiffness compared to acetaminophen extended release when dosed at nearly the daily limit (3,900mg, 4,000mg maximum).


The purpose of this review is to compare the published clinical efficacy data of DSG to that of acetaminophen extended-release (AER) and acetaminophen sustained-release (ASR) for treatment of knee OA symptoms.

Study Methodology

Retrospective evaluation of published placebo-controlled trials that used the Western Ontario and McMasters Osteoarthritis Index (WOMAC)4 to examine the efficacy of DSG 1% to AER or ASR in the treatment of knee OA.


ASR did not achieve statistically significant efficacy vs placebo for WOMAC pain, physical function or stiffness subscales.

DSG 1% demonstrated statistically significant and clinically meaningful efficacy in all WOMAC subscales vs placebo.

AER demonstrated statistically significant efficacy vs placebo in some WOMAC endpoints at 3900 mg/day, nearly the maximum daily limit for acetaminophen (4000mg/day).

% reduction from baseline vs placebo is approximately 1.5 times greater for DSG 1% than for AER (3900mg/day).


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