Acts through cyclo-oxygenase-2 (COX-2) inhibition, striking inflammation at its source

Learn how diclofenac reduces inflammation by inhibiting prostaglandin biosynthesis through action on the COX enzymes with selectivity for COX-2, and inhibiting phospholipase A2 activity to reduce the production of inflammatory leukotrienes.1,2,4

Relative potency of diclofenac, ketoprofen and ibuprofen

Diclofenac is a potent anti-inflammatory agent1

Its effect on the COX-2 enzyme means that, unlike non-NSAID medications such as paracetamol, diclofenac not only provides pain relief but also treats inflammation – a root cause of pain.2,4

Diclofenac, an NSAID (and therefore in the same drug class as ketoprofen and ibuprofen), shows marked potency in its inhibition of the COX-2 enzyme.5

Diclofenac targets inflammation to fight pain at its source

Diclofenac-containing products

Voltaren Triple Effect 1.16% Emulgel

Iodex Ultragel 1.16% Emulgel

Iodex Ultragel 1.16% Emulgel contains 1.16% diclofenac diethylamine and is an effective alternative to over-the-counter oral analgesics.2,6,7

Indicated for relief of pain and swelling in soft-tissue injuries and localised forms of soft-tissue rheumatism, and relief of non-serious arthritis of the knee or fingers.2

See the evidence for Iodex Ultragel.

Diclofenac – a potent anti-inflammatory ingredient1

Voltaren Logo

Skin Hydration and cooling effect produced by the Voltaren vehicle gel

Evidence based review in more than 3000 patients shows topical Diclofenac effective & well tolerated in painful and inflammatory conditions


Cochrane review on acute and chronic pain in adults

Cochrane review on acute and chronic pain in adults

Topical analgesics for acute and chronic pain in adults- an overview of Cochrane review.


Educational resources

Voltaren efficacy in acute neck pain

Efficacy and Safety of Diclofenac diethylamine 1.16% gel in acute neck pain