Iodex Ultragel 1.16% Emulgel

Triple Effect with NoMess cap product image

A formulation designed for fast absorption6,7

After topical application, diclofenac penetrates through the skin and into the tissues beneath.8It is retained in the muscle and other tissues that are often the source of pain.8,9

When it comes to topical NSAIDs, formulation can be more important than concentration.10

The Emulgel formulation possesses the advantages of both gels and emulsions, favouring rapid absorption, ease of application and good accepta4,5bility to patients. 7,11,12

IodexUltragel 3x effective refief (Voltaren Triple Effect) penetrates through the skin to a depth of up to 1 cm, enabling targeted action against pain and inflammation.4,5


Graph showing pain relief with Voltaren Triple Effect versus placebo

Effective relief of pain and reduction of inflammation1–3

In a randomised, double-blind, placebo-controlled study of patients with acute neck pain, Voltaren Triple Effect delivered significantly greater reduction in pain-on-movement and pain-at-rest – over three times that of placebo. Additionally, recovery time was about twice as fast as placebo.1*

*Recovery time was defined as a clinically relevant decrease in pain plus an increase in neck function.72 patients with acute neck pain received 2 g Voltaren Triple Effect (1.16%) Emulgel four times daily or placebo for 5 days.

NNT data for Voltaren Triple Effect versus other NSAIDs

The lowest number-needed-to-treat (NNT) vs other topical NSAIDs in acute musculoskeletal pain3,13

A Cochrane Review comparing topical NSAIDs and placebo showed favourable efficacy for Voltaren Emulgel* vs other treatments. Of all topical NSAIDs tested for treatment of acute musculoskeletal pain, Voltaren Emulgel had the lowest NNT.3,13‡ with pain relief reported as similar to oral NSAIDs.

This means that for every single patient you treat with Voltaren Emulgel over other topical NSAIDs, you have a better chance of giving them the significant pain relief that helps get them back on their feet and enjoying life again.3

*1% and 2% Voltaren Emulgel formulations included in the review.
†For treatment of strains, sprains or sports or overuse-type injuries.
‡vs topical ibuprofen, ketoprofen, benzydamine, piroxicam and indomethacin.

Very low systemic absorption

Applying Iodex Ultragel

Iodex Ultragel has a reduced systemic side-effect risk15,16

The low systemic absorption of Iodex Ultragel means that it has a reduced risk of systemic side effects.8,15,16*

*There is an increased risk of mild dermatological side effects (e.g. skin irritation) with topical diclofenac, but this is non-serious and reversible.

Supported by guidance from NICE

First-line medication use

To improve pain, inflammation and recovery after sprains and strains, guidance from the National Institute for Health and Care Excellence (NICE) recommends using topical NSAIDs or paracetamol as initial analgesics for soft-tissue injuries.17

Patients should also be advised not to apply heat to the injury during the first 72 hours.17

Recommend Iodex Ultragel to your patients for reduction of muscle pain and inflammation

Triple Effect with NoMess cap product image

Iodex ultra gel 1.16% Emulgel

For patients suffering from osteoarthritis knee, low back pain,Musculoskeletal pain.

Iodex Ultragel excipients

  • Raw Material Code

    Ingredient Name






    SPE-903955 Diethylamine
    SPE-903957 Perfume cream 45/3
  • For cutaneous use only. Patients should consult their doctor if the condition does not improve or worsens within 7 days of starting treatment.

    The duration of treatment depends on the indication and clinical response. The product should not be used for more than 14 days for soft-tissue injuries or soft-tissue rheumatism, or 21 days for arthritis pain, unless recommended by a doctor.

    Adults and adolescents aged 12 and over

    Voltaren Triple Effect 1.16% Emulgel should be applied over the affected area three or four times daily and rubbed gently into the skin. The amount needed depends on the size of the painful area: 2 g to 4 g (cherry to walnut sized) is sufficient to treat an area of about 400–800 cm2. After application, the hands should be washed, unless they are the site being treated, and unless the NoMess applicator is used.

    Do not apply to cuts, open wounds or any other area where the skin is damaged.

    After rubbing the gel into the skin, non-occlusive bandages can be used, however without an airtight dressing.

    Allow at least four hours between applications of the gel. Do not apply more than four times in any 24-hour period.

  • The possibility of experiencing systemic adverse events (those associated with the use of systemic forms of diclofenac) should be considered if topical diclofenac is used at a higher dosage or for a longer period of time than recommended. Topical diclofenac should be applied only to intact, non-diseased skin, and not to skin wounds or open injuries. It should not be allowed to come into contact with the eyes or mucous membranes, and should not be ingested. Discontinue the treatment if a skin rash develops after applying the product.

    Topical diclofenac can be used with non-occlusive bandages but should not be used with an airtight occlusive dressing.

    Contains propylene glycol esters, which may cause mild, localised skin irritation in some people.

    Contains benzyl benzoate which may cause mild, localised skin irritation in some people.


    • Known hypersensitivity to diclofenac or to any of the excipients
    • Patients in whom asthma, angioedema, urticaria, or acute rhinitis are precipitated by acetylsalicylic acid or other NSAIDs
    • During the last trimester of pregnancy

    For the full description of special warnings and precautions with Voltaren Triple Effect 1.16% Emulgel, please consult your local Summary of Product Characteristics.

  • The following convention has been utilised for the classification of undesirable effects: very common (≥ 1/10) common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000):

    Body system

    Adverse reaction


    Infection and infestation

    Rash pustular

    Very rare

    Immune system disorders

    Angioedema, hypersensitivity (including urticaria)

    Very rare

    Respiratory, thoracic and mediastinal disorders


    Very rare

    Skin and subcutaneous tissue disorders Dermatitis (including contact dermatitis), rash, erythema, eczema, pruritus Common
    Dermatitis bullous Rare
    Photosensitivity reaction Very rare

    For the full list of adverse reactions with Voltaren Triple Effect 1.16% Emulgel, please consult your local Summary of Product Characteristics.

Iodex Ultragel − relieves pain, reduces inflammation and speeds up the natural healing process1–3

Man clutching ankle

Musculoskeletal pain

Learn more about strains and sprains and how they can be relieved.


Educational resources

Educational resources

Access detailed clinical information on Voltaren Triple Effect Emulgel.


Patient care resources

Patient care resources

Download information on muscle pain.