Day & Night Nurse

Day & Night Nurse Capsules. (Day capsule: Paracetamol 500 mg, pseudoephedrine hydrochloride 30 mg, pholcodine 5 mg. Night capsule: Paracetamol 500 mg, promethazine HCl 10 mg, dextromethorphan HBr 7.5 mg). Indications: Symptomatic relief of colds, chills and influenza. Dosage: Adults and children 16 years and over: Day Capsules: 2 capsules every 4 hours. Max 3 doses in 24 hours. Min dosage interval: 4 hours. Night Capsules: 2 capsules before bed. Max 1 dose per night. Wait at least 4 hours after last dose of Day capsules before taking. Max duration of use without medical advice: 3 days. Contraindications: Hypersensitivity to any of the ingredients or excipients, hyperexcitability, patients using other sympathomimetics or monoamine oxidase inhibitors (MAOIs) or for two weeks after stopping MAOI treatment. Patients taking oxazolidinone antibiotics, beta blockers or antihypertensives, or those with severe hypertension or severe coronary artery disease, severe renal impairment, bronchiolitis or bronchiectasis with or at risk of developing, respiratory failure. Warnings and precautions: Contains paracetamol. Medical advice must be sought before taking this product in people with hepatic impairment, mild to moderate renal impairment, chronic or persistent cough, depleted glutathione levels, glaucoma, hypertension or cardiovascular problems, prostatic hypertrophy, urinary retention, epilepsy, diabetes, hyperthyroidism and phaeochromocytoma, psychosis, those undergoing surgery or those taking tricyclic antidepressants, SSRI's, drugs which cause CNS depression and anticholinergics. Discontinue immediately and seek medical advice with sudden abdominal pain or rectal bleeding or other symptoms of ischaemic colitis. Stop use immediately with sudden loss of vision, decreased visual acuity or if severe skin reactions or fever occur within the first 2 days of treatment. Use with caution: in the elderly, who are more likely to experience confusion and paradoxical excitation.  Alcohol should be avoided. Prolonged use may lead to addiction, even at therapeutic doses. Should not be used with other paracetamol-containing products, decongestants, antihistamines (including those used on the skin) or cough and cold medicines. With patients with a history of drug abuse including dextromethorphan abuse, and those who are slow metabolizers of CYP2D6 or use CYP2D6 inhibitors or those taking vasoconstrictive agents. Do not use in those with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. May cause urine pregnancy tests to produce false results. Should not be used in pregnancy or whilst breast feeding without medical advice. Immediate medical advice should be sought in the event of an overdose. Side effects: See SPC for full details. Hypersensitivity reactions including anaphylaxis, drug dependence and drug withdrawal syndrome, skin rashes, SJS, drowsiness, dizziness, nausea, vomiting, abdominal discomfort, dry mouth, thrombocytopenia, bronchospasm, hepatic dysfunction, confusion, disorientation, paradoxical excitation, increased blood pressure, tachycardia, palpitations, blurred vision and urinary retention. Legal category: P. Product licence number: PL 44673/0068. MAH: GlaxoSmithKline Consumer Healthcare (UK) Trading Limited, Brentford, TW8 9GS, U.K. RRP (excl. VAT): £7.08 Text prepared: August 2022