Stannous fluoride formulation

Sensodyne Rapid Relief is specially formulated with stannous fluoride

Engineered for speed: stannous fluoride formulation with bio-adhesive polymer gives fast relief from dentine hypersensitvity.^1,2

Stannous fluoride formulation accelerates occlusion of exposed dentine tubules

The unique formulation – with a balance of active stannous fluoride and bio-adhesive polymer – accelerates occlusion of dentine tubules by:1

Providing improved bio-adhesion*³
Forming a gel-like scaffold to hold the stannous in place¹

*vs. toothpaste containing 0.454% stannous fluoride and lower polymer level

Study summary

The Sensodyne Rapid Relief stannous fluoride formulation occludes exposed dentine tubules, helping prevent the movement of fluid^1,3–5

Representative FIB-SEM image of dentine tubules treated with Sensodyne Rapid Relief, combining multiple imaging techniques (STEM-EDS, DSIMS, FIB-SEM/EDS). The stannous fluoride formulation is shown to extend up into the dentine tubules.^4,5

DSIMS, dynamic secondary ion mass spectrometry; FIB-SEM/EDS, focused ion beam scanning electron microscope/energy-dispersive spectroscopy; STEM-EDS, scanning transmission electron microscope energy-dispersive spectroscopy

Clinical summary

Clinically proven fast relief^6–8

Stannous fluoride is delivered in an anhydrous (non-aqueous) formulation that is primed to react in the mouth
The non-aqueous formulation ensures stannous fluoride becomes active when in contact with saliva

The facilitating polymer becomes adhesive in saliva, sticking to dentine and helping to trap stannous ions
Engineered for speed – a unique formulation that accelerates occlusion of exposed dentine tubules¹

Sensodyne Rapid Relief has a unique formulation of stannous fluoride with facilitating bio-adhesive polymer, and has been shown to reduce fluid flow through dentine tubules by 127% compared with a regular stannous fluoride toothpaste after one application in vitro.*¹

Chart adapted from Khan et al. 2017¹SnF₂, stannous fluoride *vs. toothpaste containing 0.454% stannous fluoride and lower polymer level. Although the active ingredients are the same, the way the toothpastes are formulated affects the way they work.¹ A four-day hydraulic conductance study measuring the fluid flow rates through dentine tubules of two toothpaste formulations. Fluid flow rates were measured after the initial treatment and on Days 1–4. The Pashley hydraulic conductance model and Earles’ solution passed through dentine tubules when a simulation of pulpal pressure was used

Study summary
Dentine tubule occlusion that can withstand exposure to dietary acids⁹

In vitro SEM images of the dentine surface after 2 minutes’ exposure to Sensodyne Rapid Relief toothpaste slurries twice daily.⁹

SEM, scanning electron microscope

Study summary
Reduction in dentine hypersensitivity after brushing sensitive areas⁶

Sensodyne Rapid Relief with stannous fluoride and bio-adhesive polymer is clinically proven to relieve sensitivity from the first brush.⁶

Chart adapted from GSK data on file 207211⁶Two additional studies have been conducted: GSK data on file 205710 showing 7% reduction in Schiff score from baseline after first brush, and GSK data on file 205697 showing 18% reduction in Schiff score from baseline after first brush⁶

Clinical summary
Reduction in dentine hypersensitivity after a single ‘dab-on’ application⁸

Sensodyne Rapid Relief with stannous fluoride and bio-adhesive polymer is clinically proven to relieve sensitivity in just 60 seconds.⁸

Chart adapted from Seong et al. 2017⁸'Dab-on' refers to direct application with finger to sensitive teeth Two additional studies have been conducted: GSK data on file 205072 showing 14% reduction in Schiff score from baseline after a single application, and GSK data on file 207212 showing 29% reduction in Schiff score from baseline after a single application

Clinical summary
Sustained relief in dentine hypersensitivity with long-term use¹⁰

A 63% reduction in dentine hypersensitivity has been shown after 8 weeks of brushing with Sensodyne Rapid Relief.¹⁰

Chart adapted from Parkinson et al. 2015¹⁰

Clinical summary