ProEmalj Science: Preventing Tooth Erosion and Maintaining Enamel

The unique formulation of ProEmalj^1–10

The unique formulation of ProEmalj delivers minerals into the enamel to help strengthen and protect^7,11

ProEmalj contains 1450ppm fluoride in an optimised formulation designed to maximise intraoral fluoride. By omitting components that inhibit fluoride uptake, which are present in many fluoride toothpastes, this unique ProEmalj dual-action formulation enhances remineralisation and inhibits demineralisation, strengthening and protecting enamel.^1–4

ProEmalj optimised formulation:

No phosphates^2,6,7
No polyvalent metal ions⁷
Ionic form of fluoride⁷
No SLS⁸
Neutral pH⁹
Low abrasivity^10,12\

SLS, sodium lauryl sulphate*Compared with tested, non-optimised fluoride toothpastes

Dual protection for stronger, more resilient enamel^7,13

The unique ProEmalj formulation actively improves mineral uptake and leaves enamel more resilient to subsequent acid challenges.^7,13

In vitro SEM images of enamel cross-sections show variations in mineral density¹⁴SEM, scanning electron microscope

Not all fluoride toothpastes are the same^5,15

Sensodyne ProEmalj maintains higher levels of fluoride

In an in situ study against a non-optimised fluoride toothpaste, the optimised ProEmalj formulation maintained higher levels of fluoride in subjects’ saliva 1 hour after brushing.³

Adapted from GSK data on file RH02217, 2014³
Sensodyne ProEmalj creates an environment in the mouth that supports fast remineralisation³

In an in situ study against a non-optimised fluoride toothpaste, the optimised ProEmalj formulation¹ maintained higher calcium bioavailability in subjects’ saliva.

Adapted from GSK data on file RH02217, 2014³
Sensodyne ProEmalj enhances remineralisation by delivering up to 3 times more fluoride uptake into enamel in vitro^†16

Up to 3X higher fluoride uptake^† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁶

In laboratory studies, ProEmalj delivered more fluoride, deeper into the enamel for superior remineralisation vs. a non-optimised fluoride toothpaste.^†16

In vitro cross-sectional DSIMS images of enamel surfacesDSIMS, dynamic secondary ion mass spectrometry^†Based on mean fluoride/oxygen ratio measured at a depth of 20μm; vs. a non-optimised fluoride toothpaste
Sensodyne ProEmalj improves mineral uptake, leaving enamel more resilient to subsequent acid challenge⁷

In an in situ study, ProEmalj increased the surface microhardness of acid-softened enamel, leaving it stronger and more resilient to dietary acid challenges,^7,17 with 25% greater surface microhardness recovery vs. a non-optimised fluoride toothpaste.⁷

Adapted from Barlow et al. 2009⁷
Sensodyne ProEmalj locks in more minerals for superior inhibition of demineralisation^*18

5X greater protection from demineralisation* in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁸

In laboratory studies, ProEmalj inhibited demineralisation of enamel, locking in more minerals vs. a non-optimised fluoride toothpaste.*¹⁸

In vitro cross-sectional BSE-SEM images of enamel surface lesionsBSE-SEM, back-scattered electrons-scanning electron microscope

*In vitro. Based on mean overall mineral loss; vs. a non-optimised fluoride toothpaste
A gentle formulation helps ensure minimal wear of acid-softened enamel¹⁰

Sensodyne ProEmalj has a low abrasion formula, helping to maintain the structural integrity of the enamel surface.*¹⁰

In vitro SEM cross-sectional images of enamel surface structure

*ProEmalj Daily Protection and ProEmalj Extra Fresh only

Sensodyne ProEmalj Toothpaste

ProEmalj products are designed to help protect against enamel wear^7,17,19–21

Sensodyne ProEmalj – helping protect your patients against enamel wear

Enamel wear

Find out more about enamel wear.

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Sensodyne ProEmalj range

Find out how the Sensodyne ProEmalj range can help your patients.

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Patient care resources

Download resources for your patients.

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References

Fowler CE et al. J Clin Dent 2009 20:178–185.
Newby CS et al. J Clin Dent 2006; 40:306 (abstr. 10).
GSK data on file RH02217. December, 2014.
GSK data on file 161181. May, 2016.
Layer TM. J Clin Dent 2009; 20:199–202.
Zero DT et al. Caries Res 2000; 34:344 (abstr. 105).
Barlow AP et al. J Clin Dent 2009; 20:192–198.
Barkvoll P et al. Caries Res 1988; 22:139–144.
Friberger P. Scand J Dent Res 1975; 83:339–344.
Creeth JE, Price KS, Wicks MA. J Clin Dent 2006; 17:106–111.
Newby CS et al. J Clin Dent 2006; 17:94–99.
GSK data on file 162366. June, 2016.
Maggio B et al. J Dent 2010; 38:S37–44.
GSK data on file 133333. 2016.
Mason S. J Clin Dent 2009; 20:175–177.
GSK data on file 161077. May, 2016.
Zero DT et al. J Clin Dent 2006; 17:112–116.
GSK data on file 161180. May, 2016.
Fowler C et al. J Clin Dent 2006; 17:100–105.
Fowler C et al. Presentation at the International Association of Dental Research. Abstract 555. June 2012.
Fowler C et al. Presentation at the International Association of Dental Research. Abstract 3386. March 2011.

This site is intended for Norway healthcare professionals only.

PM-NO-PRO-21Date of Preparation: Jan 2022

ProEmalj Science: Preventing Tooth Erosion and Maintaining Enamel

The unique formulation of ProEmalj1–10

Dual protection for stronger, more resilient enamel7,13

Up to 3X higher fluoride uptake† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste16

5X greater protection from demineralisation* in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste18

Sensodyne ProEmalj Toothpaste

Sensodyne ProEmalj – helping protect your patients against enamel wear

Enamel wear

Sensodyne ProEmalj range

Patient care resources

References

The unique formulation of ProEmalj^1–10

Dual protection for stronger, more resilient enamel^7,13

Up to 3X higher fluoride uptake^† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁶

5X greater protection from demineralisation* in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁸