Product Information: Please refer to the Summary of Product Characteristics for full product information.
Night Nurse Cold Remedy Oral Solution / Night Nurse Capsules (paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide). Indications: Symptomatic relief of colds, chills and influenza, including cough at night. Dosage: Adults and children 16 years and over: 20 ml or 2 capsules before bed. Max 1 dose in 24 hours. Max duration of use without medical advice: 7 days. Contraindications: Hypersensitivity to the active ingredients or excipients. Hepatic or renal impairment. Patients with or at risk of developing, respiratory failure. Patients who are taking or have taken monoamine oxidase inhibitors (MAOIs) in the last two weeks. Use in children under 16 years of age. Precautions: Contains paracetamol. Do not use with any other paracetamol-containing products, antihistamines or cold and flu medicines. Paracetamol overdose may cause liver failure. Avoid alcohol and decongestant containing medicines. Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol. Patients with rare hereditary problems of galactose intolerance, the Lapp lactose deficiency or glucose-galactose malabsorption should not take this medicine. Consult doctor before use if patient is taking warfarin or has asthma or other respiratory disorders, epilepsy, glaucoma, urinary retention, prostatic hypertrophy or cardiovascular problems. Seek medical advice before use in patients with severe renal or severe hepatic impairment, taking other medication, including tricyclic antidepressants; selective serotonin reuptake inhibitors (SSRI); drugs which cause CNS depression; or drugs with anticholinergic effects, and/or are under the care of a physician. Seek medical advice before use in people with chronic or persistent cough, such as occurs with asthma and emphysema, chronic bronchitis or where cough is accompanied by excessive secretions and then only used Night Nurse under medical supervision. Use with caution ; in patients who are slow metabolizers of CYP2D6 or use CYP2D6 inhibitors; patients with pronounced bradycardia, cardiovascular disease, with a hereditary form of prolongation of the QT interval and concomitant use with other products leading to QT prolongation; adolescents and young adults as well as in patients with a history of drug abuse or psychoactive substances due to cases of dextromethorphan abuse and dependence having been reported; in the elderly, who are more likely to experience anticholinergic adverse effects including confusion and paradoxical excitation. Avoid use in elderly patients with confusion. Concomitant use with serotonergic agents can result in serotonergic effects, including serotonin syndrome. If serotonin syndrome is suspected discontinue Night Nurse. Caution, regarding paracetamol, if used at therapeutic doses for a prolonged period or administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism). If suspected, discontinue use promptly and monitor closely, including measurement of urinary 5-oxoproline. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. May cause urine pregnancy tests to produce false results. Oral solution only: Contains 18% v/v ethanol. Harmful for those suffering from alcoholism. To be considered in pregnant or breast-feeding women, children and high-risk groups. Contains 37mg sodium per dose, consider for those on a low sodium diet. Contains 12.8g glucose, consider in patients with diabetes mellitus. Side effects: See SPC for full details. Paracetamol side effects are very rare, and whilst dextromethorphan adverse effects may occur occasionally the data is insufficient to determine frequency. Promethazine: Very common: Drowsiness. Common: Psychomotor impairment, dizziness, restlessness, disturbance in attention, headache, blurred vision, dry mouth. Legal category: Supply through pharmacy only. Product licence number: Night Nurse Cold Remedy: PA 0678/014/001, Night Nurse Capsules: PA 0678/021/001. MAH: Haleon Ireland Limited, Clocherane, Youghal Road, Dungarvan, Co. Waterford, X35 Y983, Ireland. Additional information is available upon request. Text prepared: Jan 2026.
Contains paracetamol, promethazine hydrochloride and dextromethorphan hydrobromide. Always read the label/leaflet.
