The science of caffeine and paracetamol

Paracetamol exerts its analgesic and antipyretic effect by inhibition of prostaglandins.1 On the other hand, the antagonism of adenosine receptors and inhibition of cyclo-oxygenase activity at some sites may explain caffeine’s adjuvant properties.2,4

Paracetamol chemical structure

Paracetamol basics

Paracetamol or acetaminophen is one of the most used analgesic and antipyretic over-the-counter drugs globally.1

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Do you know that contrary to popular belief, caffeine is not considered an addictive compound?3

Caffeine chemical structure

Caffeine basics

First discovered in 850 A.D., caffeine was extracted as an active compound in 1819. It is the most common legal psychoactive drug and is a chemical relative of theophylline (used in treatment of asthma).2,3 Known for some of its effects such as increasing metabolic activity and heart rate, alertness, wakefulness and concentration, it is now combined with analgesics to increase absorption from the stomach.2,3

Discover the Panadol range with paracetamol and caffeine

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Panadol Extra

The combination of paracetmol and caffeine is a well established analgesic combination.16

It is recommended for use as an analgesic in the relief of mild to moderate pain such as is associated with rheumatism, headache, symptoms of colds, influenza, sore throat, feverishness, feverish colds, toothache and dysmenorrhoea.

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Woman with migraine


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Patient relieved from migraine pain

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