Night Nurse Cold Remedy Oral Solution / Night Nurse Capsules (paracetamol, promethazine hydrochloride, dextromethorphan hydrobromide). Indications: Symptomatic relief of colds, chills and influenza, including cough at night. Dosage: Adults and children 16 years and over: 20 ml or 2 capsules before bed. Max 1 dose in 24 hours. Max duration of use without medical advice: 7 days. Contraindications: Hypersensitivity to the active ingredients or excipients. Hepatic or renal impairment. Patients with or at risk of developing, respiratory failure. Patients who are taking or have taken monoamine oxidase inhibitors (MAOIs) in the last two weeks. Use in children under 16 years of age. Precautions: Contains paracetamol. Do not use with any other paracetamol-containing products, antihistamines or cold and flu medicines. Paracetamol overdose may cause liver failure. Avoid alcohol. Medical advice should be sought if taking warfarin. Caution in patients with chronic or persistent cough, or where cough is accompanied by excessive secretions, narrow angle glaucoma, cardiovascular problems, prostatic hypertrophy, urinary retention, epilepsy, glutathione depleted states and glucose-galactose malabsorption, history of dextromethorphan abuse and dependence, poor metabolizers of CYP2D6. Concomitant use with serotonergic agents can result in serotonergic effects, including serotonin syndrome. Use with caution in the elderly. Caution, regarding paracetamol, if used at therapeutic doses for a prolonged period or administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism). If suspected, discontinue use promptly and monitor closely, including measurement of urinary 5-oxoproline. Use with caution in those with pronounced bradycardia, cardiovascular disease, a hereditary form of QT prolongation and concomitant use with other products leading to QT prolongation. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. May cause urine pregnancy tests to produce false results. Oral solution only: Patients suffering from alcoholism, diabetes mellitus or on a low sodium diet. Side effects: See SPC for full details. Paracetamol side effects are very rare, and whilst dextromethorphan adverse effects may occur occasionally the data is insufficient to determine frequency. Promethazine: Very common: Drowsiness. Common: Psychomotor impairment, dizziness, restlessness, disturbance in attention, headache, blurred vision, dry mouth. Legal category: Supply through pharmacy only. Product licence number: Night Nurse Cold Remedy: PA 0678/014/001, Night Nurse Capsules: PA 0678/021/001. MAH: Haleon Ireland Limited, Clocherane, Youghal Road, Dungarvan, Co. Waterford, X35 Y983, Ireland. Full product information is available in the SPC. Additional information is available upon request. Text prepared: July 2025.
