Oleyl Alcohol
Understanding the role of Permeation Enhancer (PE)
Differentiating between PE used in different formulation of same product
‘Formulation matters’ to deliver the active ingredient efficiently into the skin layers1
Formulation describes the way in which the different chemicals in a medicine are combined This means that two products with the same active ingredients, but different formulations can have different effects
Effect of permeation enhancer in a topical formulation2
Permeation enhancer allows increase amount of active ingredient from the topical formulation to penetrate through the stratum corneum by ‘softening the mortar (lipids) & increasing the fluidity’2
A good permeation enhancer should possess3,4
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Minimal disruption
Minimal disruption
It allows native skin barrier to return to its original state rapidly to continue protecting the body from unwanted water loss, irritants and allergens5
Optimal permeation
It facilitates the delivery of therapeutic amounts of active drug (API) across the native skin barrier5
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Not all permeation enhancers are the same!
The visualisation explains the effect of two PEs Oleyl alcohol Oleic acid on the skin barrier
1-Bigger head of Oleic acid tears the skin . The skin barrier takes longer to come back to its natural state compared to Oleyl alcohol use in Voltaren3
The Voltaren range offers pain-relief products tailored to individual patient needs
Voltaren 2.32% Emulgel
Relief Gel for joint, back and body pain
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