Voltaren Overview
Voltaren – bring back the joy of movement for your patients
The Voltaren range of products provides effective relief of body pain to help patients rediscover the joy of movement.
Why choose Voltaren for your patients?
Dermal Reservoir Technology12
Voltaren products contain the potent non-steroidal anti-inflammatory drug (NSAID), diclofenac.3,11
The formulation creates a reservoir of diclofenac within the skin for sustained release and oleyl alcohol plays a critical role as a permeation enhancer for better absorption12
Voltaren Penetrates Deep Through the Skin
Voltaren is an emulgel, a non-greasy formulation that combines a cooling water-based gel with a lipid-phase in a gel and cream for topical application. It is specially designed to penetrate deep through the skin to deliver effective arthritis pain relief.5,6
Low systemic absorption, for a lower risk of systemic side effects1,2
The topical application of Voltaren Gel leads to a low systemic exposure meaning a reduced risk of systemic side effects and drug-drug interactions.1,2
Dermal Reservoir Technology
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The science behind Voltaren
Targeting pain with the potent anti-inflammatory effects of diclofenac3
Voltaren is specially designed to penetrate deep through the skin and accumulates in the synovial tissue while producing a sustained analgesic effect. The combination of reservoir technology and permeation enhancers optimizes absorption, ensuring consistent pain relief at the source of inflammation12. When applied as directed, Voltaren is retained in the following2:
Subcutaneous tissue (the layer that underlies the skin) at a mean concentration of up to 91 ng/ml
Muscle at a mean concentration of up to 63 ng/g
Synovial tissue at a mean concentration of up to 20 ng/ml
Synovial fluid at a mean concentration of up to 26 ng/ml
Epidermal Reservoir formation proven by Raman spectroscopy
Study proved efficient delivery of diclofenac molecule into the target inflamed tissues.
Visualization of Epidermal Reservoir Formation with Voltaren emulgel7
In 2020, Zhang et al. published a proof-of-concept study in the Journal of Pain Research for all Voltaren gels (2.32% DDEA) demonstrating the permeation of diclofenac into the skin layers and forming a reservoir7.
The above Raman spectroscopy images demonstrated that7:
Topical gels deliver diclofenac through the stratum corneum skin barrier and form a drug depot localized in the epidermis.
Diclofenac is efficiently delivered to the inflamed tissues through sustained drug release rather than systemic redistribution.
This data is in line with earlier clinical findings that this depot acts like a true reservoir and enabled sustained drug release.8-10
Explanation of image:
The images on the left above show the Raman Spectroscopy visualization of the relative diclofenac concentration in the skin after the topical application of DDEA 2.32%. The red colour indicates the highest concentration of DDEA within the epidermis, where it forms a reservoir, confirming that DDEA penetrates through the stratum corneum.
DDEA: Diclofenac Diethylamine
The Voltaren range offers pain-relief products tailored to individual patient needs
Voltaren 2.32% Emulgel
Relief Gel for joint, back and body pain
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