Panadol overview

Worried young man wearing face mask holding his face using his both hands

The world’s leading range for the treatment of symptoms of cold and flu

The Panadol Cold & Flu range contains clinically proven active ingredients to fight multiple symptoms*

* Align with LOC SmPC

Panadol – relief from cold and flu symptoms^1-10

Cold symptoms relief

Panadol products relieve the eight most bothersome symptoms of colds and flu:fever, sinus congestion, headache, muscle pain, body pain, nasal congestion, sinus pain, and sore throat pain.^1-10

Effective combination

Panadol products are powerful, multi-action, convenient, and well tolerated combinations that are suitable for active, busy patients, who need to stay alert.^1-10

Strong scientific evidence

Multiple clinical studies, published in international, peer-reviewed journals, showed the strength of Panadol products for relieving cold and flu symptoms.^3,5-10

Panadol – in-depth patient understanding

Cold symptoms are common and bothersome

Control the most bothersome and frequent symptoms of colds and flu

Cold and flu symptoms are frequent and bothersome. These symptoms include: fever (elevated body temperature), nasal congestion (a blocked nose), rhinorrhoea (a runny nose), sinus pressure and pain (headaches), sneezing (blowing your nose often), sore throat (pain in the pharynx), and body aches (pain all over the body). The Panadol range offers various options of clinically proven products, to relieve these symptoms.^1-10

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Prevalence of the condition

Are your patients experiencing cold and flu symptoms?

Between 5-10% of adults worldwide get a cold/flu every year.¹¹

On average, adults get 4 to 6 colds per year, while children get 6 to 8 of them.¹²
Patients’ daily lives are impacted by cold and flu symptoms

Cold and flu symptoms can have a major impact:

Impact on daily life

52% of people stated that a cough/cold had a significant effect on their daily life.¹³

Reduced productivity

People reported a productivity decrease of 26%.¹³

Decreased work/school attendance

Nearly 50% of people reported missing work or school for 1-2 days.¹³

Disturbed/poor sleep

Total sleep time decreased by an average of 23 minutes.¹⁴

Performance reduction

Reduced performance, mood, reaction time, and cognitive performance, was reported.^13,15-17

The Panadol range is specially formulated for clinically proven relief from the symptoms of colds and flu^1-10

Paracetamol

Paracetamol is an over-the-counter drug used for pain relief and fever. It provides effective and sustained fever control, which starts to relieve fever in 30 minutes for up to 6 hours.³

Phenylephrine hydrochloride

Phenylephrine is a sympathomimetic decongestant that has a potent vasoconstrictive effect on the capillaries in the nasal lining, which in turn leads to a reduction in the swelling of the nasal mucosa, thereby reducing congestion.⁶

Caffeine

Caffeine is an analgesic adjuvant for paracetamol that increases mental alertness and improves wakefulness.^21-23

The Panadol range offers clinically proven solutions tailored to individual patient needs^1–10

Panadol C&F Day

Panadol C&F Day provides powerful and effective relief against cold and flu symptoms, with caffeine to produce a synergistic effect with paracetamol.^{3,4,6,8-10,18-20,24-31}

Key ingredients:Paracetamol 50mg, phenylephrine 5mg, and caffeine 25mg

The Panadol range – the world’s leading cold and flu products

Colds

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Patient resources

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References

Centers for Disease Control and Prevention. 2018. Cold Versus Flu.
Eccles R et al. Open J Resp Dis 2014; 4:73–8230.
Bachert C et al. Clin Ther 2005; 27:993–1003.
Eccles R. J Clin Pharm Ther 2006; 31:309-319.
Horak F et al. Ann Allergy Asthma Immunol 2009; 102:116–120.
Kollar C et al. Clin Ther 2007; 29:1057-1070.
Cohen BM. Eur J Clin Pharmacol 1972; 5:81–86.
Schachtel BP et al. Clin Pharmacol Ther 1988; 44:704–711.
D’Agostino RB et al. Clin Pharmacol Ther 1998; 64:579–596.
Derry CJ et al. Cochrane Database Syst Rev 2014; 12:CD009281.
National Advisory Committee on Immunization. Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017–2018.
Worrall G. Can Fam Physician 2011; 57:1289–1290.
Dicpinigaitis PV et al. Curr Med Res Opin 2015; 31:1519–1525.
Drake CL et al. Physiol Behav 2000; 71:75–81.
Smith AP. Psychoneuroendocrinology 2013; 38:744–751.
Thomas M et al. Ergonomics 2000; 43:1342–1349.
Smith A et al. Psychoneuroendocrinology 1998; 23:733–739.
Eccles R. Lancet Infect Dis 2005; 5:718–725.
Doyle WJ et al. Pediatr Infect Dis J 1988; 7:229–238.
Brayfield A. Martindale: The Complete Drug Reference. 38 ed. London: Pharmaceutical Press; 2014.
Iqbal N et al. Biopharm Drug Dispos 1995; 16:481-487.
Laska EM et al. JAMA 1984; 251:1711–1718.
Shapiro RE. Neurol Sci 2007; 28:S179–S183.
Blaiss MS et al. Curr Med Res Opin 2015; 31:1527–1538.
Brunton L et al. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12 ed. New York, NY: McGraw-Hill Medical; 2011.
Burnett I et al. Clin Ther 2006; 28:1273–1278.
Chua SS et al. Biopharm Drug Dispos 1989; 10:1–14.
Empey DW et al. Drugs 1981; 21:438–443.
Peters BH et al. Am J Med 1983; 74:36–42.
Prescott LF. Am J Ther 2000; 7:143–147.
Whelton A. Am J Ther 2005; 12:43–45.

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